 | |
| Names | |
|---|---|
| Preferred IUPAC name (4aR,8aR)-5-Propyl-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrazolo[3,4-g]quinoline | |
| Other names LY-171555; LY171555; LY-171,555 | |
| Identifiers | |
3D model (JSmol) | |
| ChEBI | |
| ChEMBL | |
| ChemSpider |
|
| MeSH | D019257 |
| UNII | |
| |
| |
| Properties | |
| C13H21N3 | |
| Molar mass | 219.33 g/mol |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Quinpirole (developmental code nameLY-171555) is apsychoactive drug andresearch chemical which acts as aselectiveD2 andD3receptoragonist. It is used inscientific research.[1][2][3] Quinpirole has been shown to increase locomotion and sniffing behavior in mice treated with it. At least one study has found that quinpirole induces compulsive behavior symptomatic ofobsessive compulsive disorder in rats.[4] Another study in rats show that quinpirole produces significantTHC-like effects when metabolic degradation ofanandamide is inhibited, supporting the hypothesis that these effects of quinpirole are mediated bycannabinoidCB1 receptors.[5] Quinpirole may also reduce relapse in adolescent rat models of cocaine addiction.[6]
Experiments in flies found quinpirole may haveneuroprotective effects againstParkinson's disease-like pathology.[7] Moreover, in primary neuronal cultures it also reduces the rate of firing in dopaminergic neurons.[7]
