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Quinelorane

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Chemical compound

Pharmaceutical compound

Quinelorane
Identifiers

IUPAC name (5aR,9aR)-6-propyl-5a,7,8,9,9a,10-hexahydro-5H-pyrido[2,3-g]quinazolin-2-amine
CAS Number	97466-90-5^Y HCl: 97548-97-5^Y
PubChemCID	57242
IUPHAR/BPS	954
ChemSpider	51604^N
UNII	Z0X4VT3Y1Q HCl: JT5527J55O^Y
KEGG	D05677^Y
ChEMBL	ChEMBL155731^N
CompTox Dashboard(EPA)	DTXSID4046315
Chemical and physical data
Formula	C₁₄H₂₂N₄
Molar mass	246.358 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCCN1CCC[C@H]2[C@H]1CC3=CN=C(N=C3C2)N
InChI InChI=1S/C14H22N4/c1-2-5-18-6-3-4-10-7-12-11(8-13(10)18)9-16-14(15)17-12/h9-10,13H,2-8H2,1H3,(H2,15,16,17)/t10-,13-/m1/s1^N Key:TUFADSGTJUOBEH-ZWNOBZJWSA-N^N
^NY (what is this?) (verify)

Quinelorane is a drug which acts as adopamine agonist for theD₂^[1]^[2]^[3] andD₃ receptor.

^Caine SB, Negus SS, Mello NK, Patel S, Bristow L, Kulagowski J, Vallone D, Saiardi A, Borrelli E (April 2002)."Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists".Journal of Neuroscience.22 (7):2977–88.doi:10.1523/JNEUROSCI.22-07-02977.2002.PMC 6758322.PMID 11923462.
^Gasior M, Paronis CA, Bergman J (January 2004). "Modification by dopaminergic drugs of choice behavior under concurrent schedules of intravenous saline and food delivery in monkeys".The Journal of Pharmacology and Experimental Therapeutics.308 (1):249–59.doi:10.1124/jpet.103.052795.PMID 14563783.S2CID 5879400.
^Brooks JM, Sarter M, Bruno JP (September 2007)."D2-like receptors in nucleus accumbens negatively modulate acetylcholine release in prefrontal cortex".Neuropharmacology.53 (3):455–63.doi:10.1016/j.neuropharm.2007.06.006.PMC 2000917.PMID 17681559.

Agonists	Benzazepines:6-Br-APB Fenoldopam SKF-38,393 SKF-77,434 SKF-81,297 SKF-82,958 SKF-83,959 Trepipam Zelandopam Ergolines:Cabergoline CY-208,243 Dihydroergocryptine LEK-8829 Lisuride Pergolide Terguride Dihydrexidine derivatives:A-77636 A-86929 Adrogolide (ABT-431, DAS-431) Dihydrexidine Dinapsoline Dinoxyline Doxanthrine Phenethylamines:BCO-001 Deoxyepinephrine (N-methyldopamine, epinine) Dopexamine Etilevodopa Ibopamine L-DOPA (levodopa) Melevodopa L-Phenylalanine L-Tyrosine XP21279 Others:A-68930 Apomorphine Isocorypalmine Nuciferine PF-6649751 PF 6669571 Propylnorapomorphine Rotigotine SKF-89,145 SKF-89,626 Stepholidine Tavapadon Tetrahydropalmatine
PAMs	Tetrahydroisoquinolines:DETQ DPTQ Mevidalen
Antagonists	Typical antipsychotics:Butaclamol Chlorpromazine Chlorprothixene Flupentixol (flupenthixol) (+melitracen) Fluphenazine Loxapine Perphenazine (+amitriptyline) Pifluthixol Thioridazine Thiothixene Trifluoperazine (+tranylcypromine) Zuclopenthixol Atypical antipsychotics:Asenapine Clorotepine Clotiapine Clozapine DHA-clozapine Fluperlapine Iloperidone Norclozapine Norquetiapine Olanzapine (+fluoxetine) Paliperidone Quetiapine Risperidone Tefludazine Zicronapine Ziprasidone Zotepine Others:Berupipam Ecopipam EEDQ Metitepine (methiothepin) Odapipam Perlapine SCH-23390