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| Names | |
|---|---|
| Preferred IUPAC name Quinazolin-4(3H)-one | |
| Other names 4(3H)-Quinazolinone; 4(1H)-Quinazolinone; 3,4-Dihydroquinazolin-4-one; 4(3H)-Quinazolone; 4-Hydroxyquinazoline; 4-Oxo-3,4-dihydroquinazoline; 4-Oxoquinazoline; 4-Quinazolinol; 4-Quinazolinone; 4-Quinazolone | |
| Identifiers | |
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3D model (JSmol) | |
| ChEMBL | |
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| Properties | |
| C8H6N2O | |
| Molar mass | 146.149 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Quinazolinone is aheterocyclic chemical compound, aquinazoline with acarbonyl group in the C4N2 ring. Twoisomers are possible: 2-quinazolinone and 4-quinazolinone, with the 4-isomer being the more common. These compounds are of interest inmedicinal chemistry.[1]
Common routes to quinazolines involve condensation ofamides to anilines with ortho nitrile, carboxylic acids and amides.[2]
Quinazolinone drugs that function ashypnotic/sedatives,methaqualone (Quaalude) for example, usually contain a 4-quinazolinone core with a 2-substitutedphenyl group at nitrogen atom 3.
