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| Trade names | Prac-tic |
| Routes of administration | Topical |
| Drug class | Ectoparasiticide |
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| Chemical and physical data | |
| Formula | C18H10Cl2F5N5S |
| Molar mass | 494.27 g·mol−1 |
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Pyriprole, sold under the brand namePrac-tic, is a veterinary medication used for dogs against external parasites such asfleas andticks.[3][4]
Pyriprole is aphenylpyrazole derivative similar tofipronil.[citation needed] Although introduced (in the 2000s) and under patent protection it is a "classic" insecticide.[citation needed][clarification needed] It is only approved in the EU and a few other countries for use on dogs.[citation needed] It is not approved for use on cats or livestock.[citation needed] It has not been introduced as an agricultural or hygiene pesticide.[citation needed]
Pyriprole applied as a spot-on is highly effective against fleas and several ticks species.[citation needed] Efficacy against fleas is comparable to that of other modern insecticidal active ingredients such as fipronil,imidacloprid orspinosad.[citation needed] As most flea spot-ons it controls existing flea and tick infestations in about 1 to 2 days, and provides about 4 weeks protection against re-infestations.[citation needed]
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Pyriprole is an insecticide andacaricide. It inhibitsγ-aminobutyric acid (GABA)-gated chloride channels (GABAA receptors) resulting in uncontrolled hyperactivity of the central nervous system of fleas and ticks.[5]
Parasites are killed through contact rather than by systemic exposure. Following topical administration pyriprole is rapidly distributed in the hair coat of dogs within one day after application. It can be found in the hair coat throughout the treatment interval. Insecticidal efficacy duration against new infestations with fleas persists for a minimum of four weeks. The substance can be used as part of a treatment strategy for the control offlea allergy dermatitis (FAD).
