Purine analogues areantimetabolites that mimic the structure of metabolicpurines.

• Nucleobase analogues
  • Thiopurines such as thioguanine are used to treat acute leukemias and remissions in acute granulocytic leukemias.
    • Azathioprine is the main immunosuppressivecytotoxic substance. Aprodrug, it is widely used in transplantation to control rejection reactions. It is nonenzymatically cleaved tomercaptopurine, a purine analogue that inhibits DNA synthesis. By preventing the clonal expansion of lymphocytes in the induction phase of the immune response, it affects bothcell immunity andhumoral immunity. It also successfully suppressesautoimmunity.
    • Mercaptopurine
    • Thioguanine
• Nucleoside analogues
  • Clofarabine
  • Pentostatin andcladribine areadenosine analogs that are used primarily to treathairy cell leukemia.
• Nucleotide analogues
  • Fludarabine inhibits multipleDNA polymerases,DNA primase, andDNA ligase I, and isS phase-specific (since these enzymes are highly active during DNA replication).

• 
  Purine
• 
  Mercaptopurine
• 
  Thioguanine
• 
  Fludarabine

Purine antimetabolites are commonly used to treat cancer by interfering with DNA replication.^[1]

Thisbiochemistry article is astub. You can help Wikipedia byadding missing information.

• v
• t
• e

• Antimetabolites
• Purines
• Biochemistry stubs

• Articles with short description
• Short description matches Wikidata
• All stub articles