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Protein-histidine pros-kinase

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Class of enzymes
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protein histidine pros-kinase
Identifiers
EC no.2.7.13.1
CAS no.99283-67-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDBPDBePDBsum
Gene OntologyAmiGO /QuickGO
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NCBIproteins

Inenzymology, aprotein-histidine pros-kinase (EC2.7.13.1) is anenzyme thatcatalyzes thechemical reaction

ATP + proteinL-histidine{\displaystyle \rightleftharpoons } ADP + proteinNπ-phospho-L-histidine

Thus, the twosubstrates of this enzyme areATP andprotein L-histidine, whereas its twoproducts areADP andprotein Npi-phospho-L-histidine.

This enzyme belongs to the family oftransferases, specifically those transferring a phosphate group to the sidechain ofhistidine residues inproteins (protein-histidine kinases). Thesystematic name of this enzyme class isATP:protein-L-histidine Npi-phosphotransferase. Other names in common use includeATP:protein-L-histidine N-pros-phosphotransferase,histidine kinase,histidine protein kinase,protein histidine kinase,protein kinase (histidine), andHK2.

References

[edit]
Transferases:phosphorus-containing groups (EC 2.7)
2.7.1–2.7.4:
phosphotransferase/kinase
(PO4)
2.7.1:OH acceptor
2.7.2:COOH acceptor
2.7.3:N acceptor
2.7.4:PO4 acceptor
2.7.6:diphosphotransferase
(P2O7)
2.7.7:nucleotidyltransferase
(PO4-nucleoside)
Polymerase
DNA polymerase
DNA-directed DNA polymerase
I/A
γ
θ
ν
T7
Taq
II/B
α
δ
ε
ζ
Pfu
III/C
IV/X
β
λ
μ
TDT
V/Y
η
ι
κ
RNA-directed DNA polymerase
Reverse transcriptase
Telomerase
RNA polymerase
Phosphorolytic
3′ to 5′exoribonuclease
Nucleotidyltransferase
Guanylyltransferase
Other
2.7.8: miscellaneous
Phosphatidyltransferases
Glycosyl-1-phosphotransferase
2.7.10–2.7.13:protein kinase
(PO4; protein acceptor)
2.7.10:protein-tyrosine
2.7.11:protein-serine/threonine
2.7.12: protein-dual-specificity
2.7.13: protein-histidine
Activity
Regulation
Classification
Kinetics
Types
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