| PTGDS | |||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | PTGDS, L-PGDS, LPGDS, PDS, PGD2, PGDS, PGDS2, prostaglandin D2 synthase | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM:176803;MGI:99261;HomoloGene:737;GeneCards:PTGDS;OMA:PTGDS - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
Prostaglandin-H2 D-isomerase (PTGDS) is anenzyme that in humans is encoded by thePTGDSgene.[5][6]
The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion ofprostaglandin H2 (PGH2) toprostaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice over-expressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep.[6] Furthermore, PTGDS and its product PGD2 are elevated in the bald-scalp areas of men with male pattern baldness (androgenetic alopecia).[7]
Prostaglandin D2 synthase is used clinically as a diagnostic marker forliquorrhea, that is, to check whether fluid leaking from the nose or ear containscerebrospinal fluid.[8] This is important in the assessment ofhead trauma severity. In a medical context, the older term "beta-trace protein" is frequently used to refer to PTGDS.
 | This article on agene on humanchromosome 9 is astub. You can help Wikipedia byexpanding it. |
