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Proscillaridin

From Wikipedia, the free encyclopedia
(Redirected fromProscillaridine A)
Chemical compound
Pharmaceutical compound
Proscillaridin
Clinical data
Other names14β-Hydroxy-3β-[α-L-rhamnopyranosyl)oxy]bufa-4,20,22-trienolide
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • 5-[(3S,8R,9S,10R,13R,14S,17R)-14-Hydroxy- 10,13-dimethyl-3-((2R,3R,4R,5R,6R)-3,4,5-trihydroxy- 6-methyltetrahydro-2H-pyran-2-yloxy)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro- 1H-cyclopenta[a]phenanthren-17-yl]-2H-pyran-2-one
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.006.702Edit this at Wikidata
Chemical and physical data
FormulaC30H42O8
Molar mass530.658 g·mol−1
3D model (JSmol)
  • O=C1OC=C([C@H]2CC[C@]3([C@@]2(CC[C@H]4[C@H]3CCC5=C[C@H](CC[C@@]54C)O[C@@H]6O[C@@H](C)[C@@H]([C@H]([C@H]6O)O)O)C)O)C=C1
  • InChI=1S/C30H42O8/c1-16-24(32)25(33)26(34)27(37-16)38-19-8-11-28(2)18(14-19)5-6-22-21(28)9-12-29(3)20(10-13-30(22,29)35)17-4-7-23(31)36-15-17/h4,7,14-16,19-22,24-27,32-35H,5-6,8-13H2,1-3H3/t16-,19-,20+,21-,22+,24-,25+,26+,27-,28-,29+,30-/m0/s1 checkY
  • Key:MYEJFUXQJGHEQK-ALRJYLEOSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Proscillaridin is acardiac glycoside, a kind of drug that can be used in the treatment ofcongestive heart failure andcardiac arrhythmia (irregular heartbeat). It is of thebufanolide type and can be obtained from plants of the genusScilla and inDrimia maritima (Scilla maritima).[1]

Theaglycone of proscillaridin isscillarenin.

References

[edit]
  1. ^Kedra M, Kedrowa S (May 1968). "[Clinical evaluation of Proscillaridin A, a glycoside of Scilla maritima]".Polski Tygodnik Lekarski.23 (19):714–6.PMID 4876207.
Bufadienolides
Bufo
Scilla
Kalanchoe
Cardenolides
Digitalis
Strophanthus
Thevetia
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