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Proquazone

From Wikipedia, the free encyclopedia
Nonsteroidal anti-inflammatory drug
Pharmaceutical compound
Proquazone
Clinical data
ATC code
Identifiers
  • 1-isopropyl-7-methyl-4-phenylquinazolin-2(1H)-one
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.041.079Edit this at Wikidata
Chemical and physical data
FormulaC18H18N2O
Molar mass278.355 g·mol−1
3D model (JSmol)
  • CC1=CC2=C(C=C1)C(=NC(=O)N2C(C)C)C3=CC=CC=C3
  • InChI=1S/C18H18N2O/c1-12(2)20-16-11-13(3)9-10-15(16)17(19-18(20)21)14-7-5-4-6-8-14/h4-12H,1-3H3 ☒N
  • Key:JTIGKVIOEQASGT-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Proquazone is anonsteroidal anti-inflammatory drug, known as an NSAID.[1]

Uses

[edit]

Proquazone is used to treatrheumatoid arthritis,osteoarthritis andankylosing spondylitis.[1] It has been trialed for use as pain relief for tension headaches.[2]

The recommended adult dose is around 450mg.[1]

Side Effects

[edit]

Often, use of Proquazone is associated withdiarrhea (up to 30% of the time).[1]

References

[edit]
  1. ^abcdClissold SP, Beresford R (May 1987). "Proquazone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in rheumatic diseases and pain states".Drugs.33 (5):478–502.doi:10.2165/00003495-198733050-00004.PMID 3297621.S2CID 195697106.
  2. ^DiSerio FJ, Friedman AP, Parno J, Singer JM (May 1985). "Proquazone for tension headache--a multicenter trial".Headache.25 (3):127–133.doi:10.1111/j.1526-4610.1985.hed2503127.x.PMID 3891682.S2CID 9283866.
pyrazolones /
pyrazolidines
salicylates
acetic acid derivatives
and related substances
oxicams
propionic acid
derivatives (profens)
n-arylanthranilic
acids (fenamates)
COX-2 inhibitors
(coxibs)
other
NSAID
combinations
Key:underline indicates initially developed first-in-class compound of specific group;#WHO-Essential Medicines;withdrawn drugs;veterinary use.
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