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Propentofylline

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Propentofylline
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • 3-methyl-1-(5-oxohexyl)-7-propyl-3,7-dihydro-1H-purine-2,6-dione
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
ECHA InfoCard100.133.568Edit this at Wikidata
Chemical and physical data
FormulaC15H22N4O3
Molar mass306.366 g·mol−1
3D model (JSmol)
  • CCCn1cnc2c1c(=O)n(c(=O)n2C)CCCCC(=O)C
  • InChI=1S/C15H22N4O3/c1-4-8-18-10-16-13-12(18)14(21)19(15(22)17(13)3)9-6-5-7-11(2)20/h10H,4-9H2,1-3H3
  • Key:RBQOQRRFDPXAGN-UHFFFAOYSA-N
  (verify)

Propentofylline (HWA 285) is axanthine derivative drug with purportedneuroprotective effects.

Pharmacology

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It is aphosphodiesterase inhibitor,[1] and also acts as anadenosine reuptake inhibitor.[1][2][3]

Uses

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Propentofylline was studied as a possible treatment forAlzheimer's disease andmulti-infarct dementia,[1][4] and has been studied, to a lesser extent, as a possible adjunct in the treatment ofischemic stroke, due to itsvasodilating properties.[5][6]

Propentofylline is in use as a veterinary medicine in older dogs.[7]

See also

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External links

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References

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  1. ^abcFrampton M, Harvey RJ, Kirchner V (2003). Frampton MA (ed.). "Propentofylline for dementia".The Cochrane Database of Systematic Reviews (2) CD002853.doi:10.1002/14651858.CD002853.PMID 12804440.
  2. ^Salimi S, Fotouhi A, Ghoreishi A, Derakhshan MK, Khodaie-Ardakani MR, Mohammadi MR, et al. (April 2008). "A placebo controlled study of the propentofylline added to risperidone in chronic schizophrenia".Progress in Neuro-Psychopharmacology & Biological Psychiatry.32 (3):726–732.doi:10.1016/j.pnpbp.2007.11.021.PMID 18096287.S2CID 21498202.
  3. ^Numagami Y, Marro PJ, Mishra OP, Delivoria-Papadopoulos M (June 1998)."Effect of propentofylline on free radical generation during cerebral hypoxia in the newborn piglet".Neuroscience.84 (4):1127–1133.doi:10.1016/S0306-4522(97)00542-3.PMID 9578400.S2CID 36155779.
  4. ^Kittner B, Rössner M, Rother M (September 1997). "Clinical trials in dementia with propentofylline".Annals of the New York Academy of Sciences.826 (1):307–316.Bibcode:1997NYASA.826..307K.doi:10.1111/j.1749-6632.1997.tb48481.x.PMID 9329701.S2CID 12493243.
  5. ^Bath PM, Bath-Hextall FJ (2004). Bath PM (ed.). "Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke".The Cochrane Database of Systematic Reviews (3) CD000162.doi:10.1002/14651858.CD000162.pub2.PMID 15266424.
  6. ^Huber M, Kittner B, Hojer C, Fink GR, Neveling M, Heiss WD (May 1993). "Effect of propentofylline on regional cerebral glucose metabolism in acute ischemic stroke".Journal of Cerebral Blood Flow and Metabolism.13 (3):526–530.doi:10.1038/jcbfm.1993.68.PMID 8478410.S2CID 24909748.
  7. ^"Launch of tablet to make life easier for dogs in old age". Yorkshire Post. 7 September 2012. Retrieved28 December 2019.
PDE1
PDE2
PDE3
PDE4
PDE5
PDE7
PDE9
PDE10
PDE11
Non-selective
Unsorted
Receptor
(ligands)
P0 (adenine)
P1
(adenosine)
P2
(nucleotide)
P2X
(ATPTooltip Adenosine triphosphate)
P2Y
Transporter
(blockers)
CNTsTooltip Concentrative nucleoside transporters
ENTsTooltip Equilibrative nucleoside transporters
PMATTooltip Plasma membrane monoamine transporter
Enzyme
(inhibitors)
XOTooltip Xanthine oxidase
Others
Others
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