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Propamocarb

From Wikipedia, the free encyclopedia
Propamocarb
Names
Preferred IUPAC name
Propyl [3-(dimethylamino)propyl]carbamate
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard100.109.082Edit this at Wikidata
UNII
  • InChI=1S/C9H20N2O2/c1-4-8-13-9(12)10-6-5-7-11(2)3/h4-8H2,1-3H3,(H,10,12)
    Key: WZZLDXDUQPOXNW-UHFFFAOYSA-N
  • InChI=1/C9H20N2O2/c1-4-8-13-9(12)10-6-5-7-11(2)3/h4-8H2,1-3H3,(H,10,12)
    Key: WZZLDXDUQPOXNW-UHFFFAOYAA
  • O=C(OCCC)NCCCN(C)C
Properties
C9H20N2O2
Molar mass188.271 g·mol−1
Density0.957 g/cm3
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
Xn
Flash point109.1 °C (228.4 °F; 382.2 K)
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
Chemical compound

Propamocarb is a systemicfungicide used for control of soil, root and leaf disease caused byoomycetes. It is used by watering or spraying. Propamocarb is absorbed and distributed through the plant's tissue.

Use

[edit]

Propamocarb has fungicidal activity only against oomycetes.

Safety

[edit]

Propamocarb has low generaltoxicity, and almost noteratogenicity orneurotoxicity formammals. It is not acarcinogen normutagen.[1][2] Propamocarb is not susceptible to formation ofresistant diseases. It is fully metabolized by plants and aquatic bacteria in a few weeks, so it is not a major ecological threat. It carries the risk of skin sensitization. OralLD50 is 2900 mg/kg for male rats and 2000 mg/kg for female rats.[2]

In one study conducted ontobacco,cucumber andspinach, using propamocarb synthesized out ofcarbon C14radionuclide, researchers stated that propamocarb is decomposed down to carbon dioxide and then incorporated into the plant's natural compounds,[2] such asamino acids.

References

[edit]
  1. ^Propamocarb Hydrochloride,United States Environmental Protection Agency
  2. ^abcPropamocarb Hydrochloride; Notice of Filing a Pesticide Petition to Establish a Tolerance for a Certain Pesticide Chemical in or on Food, Federal Register, Vol. 69, No. 47, March 10, 2004
Enzyme
(modulators)
ChATTooltip Choline acetyltransferase
AChETooltip Acetylcholinesterase
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Transporter
(modulators)
CHTTooltip Choline transporter
VAChTTooltip Vesicular acetylcholine transporter
Release
(modulators)
Inhibitors
Enhancers
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