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Propacetamol

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Propacetamol
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration
IV[1][2]
ATC code
Pharmacokinetic data
Eliminationhalf-life2.4 hours[1]
ExcretionRenal
Identifiers
  • 4-(acetamido)phenylN,N-diethylglycinate
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
ECHA InfoCard100.060.336Edit this at Wikidata
Chemical and physical data
FormulaC14H20N2O3
Molar mass264.325 g·mol−1
3D model (JSmol)
  • CCN(CC)CC(=O)OC1=CC=C(C=C1)NC(=O)C
  • InChI=1S/C14H20N2O3/c1-4-16(5-2)10-14(18)19-13-8-6-12(7-9-13)15-11(3)17/h6-9H,4-5,10H2,1-3H3,(H,15,17)
  • Key:QTGAJCQTLIRCFL-UHFFFAOYSA-N
  (verify)

Propacetamol is aprodrug form ofparacetamol which is formed fromesterification of paracetamol, and thecarboxylic acid diethylglycine. This has the advantage of making it more water-soluble. It is used in post-operative care and is delivered byI.V.[2] It is given if the patient is unable to take oral or rectally delivered paracetamol andnonsteroidal anti-inflammatory drugs (NSAIDs) are contraindicated. The onset of analgesia from propacetamol is more rapid than paracetamol given orally.[3]2 grams of propacetamol are equivalent to 1g of paracetamol.[4]

See also

[edit]

References

[edit]
  1. ^abBannwarth B, Netter P, Lapicque F, Gillet P, Péré P, Boccard E, Royer RJ, Gaucher A (1992)."Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol".British Journal of Clinical Pharmacology.34 (1):79–81.doi:10.1111/j.1365-2125.1992.tb04112.x.PMC 1381380.PMID 1633071.
  2. ^abBinhas M, Decailliot F, Rezaiguia-Delclaux S, Suen P, Dumerat M, François V, Combes X, Duvaldestin P (2004)."Comparative effect of intraoperative propacetamol versus placebo on morphine consumption after elective reduction mammoplasty under remifentanil-based anesthesia: a randomized control trial [ISRCTN71723173]".BMC Anesthesiology.4 (1): 6.doi:10.1186/1471-2253-4-6.PMC 520811.PMID 15367329.
  3. ^Moller PL, Sindet-Pedersen S, Petersen CT, Juhl GI, Dillenschneider A, Skoglund LA (2005)."Onset of acetaminophen analgesia: comparison of oral and intravenous routes after third molar surgery".British Journal of Anaesthesiology.94 (5):642–648.doi:10.1093/bja/aei109.PMID 15790675.
  4. ^Flouvat B, Leneveu A, Fitoussi S, Delhotal-Landes B, Gendron A (2004). "Bioequivalence study comparing a new paracetamol solution for injection and propacetamol after single intravenous infusion in healthy subjects".International Journal of Clinical Pharmacology and Therapeutics.42 (1):50–57.doi:10.5414/cpp42050.PMID 14756388.
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