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Presumptive and confirmatory tests

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Presumptive tests, inmedical andforensic science, analyze a sample and establish one of the following:

  1. The sample is definitely not a certain substance.
  2. The sample probably is the substance.

For example, theKastle–Meyer test will show either that a sample is not blood or that the sample is probably blood, but may be a less common substance. Furtherchemical tests are needed to prove that the substance is blood.

Confirmatory tests are the tests required to confirm the analysis. Confirmatory tests cost more than simpler presumptive tests so presumptive tests are often done to see if confirmatory tests are necessary.

Similarly, in medicine, a presumptive diagnosis identifies the likely condition of a patient, and a confirmatory diagnosis is needed to confirm the condition.

Examples

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FDA recommendations

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The USFood and Drug Administration issued aPremarket Submission and Labeling Recommendations for Drugs of Abuse Screening Tests. Its availability was announced in the Federal Register, Vol. 68, No. 231 on December 2, 2003 and is listed under "Notices." Presumptive testing has found widespread use by employers and public entities. Most people who take a drug test take a presumptive test, cheaper and faster than other methods of testing. However, it is less accurate and can render false results. The FDA recommends for confirmatory testing to be conducted and the placing of a warning label on the presumptive drug test: "This assay provides only a preliminary result. Clinical consideration and professional judgment should be applied to any drug of abuse test result, in evaluating a preliminary positive result. To obtain a confirmed analytical result, a more specific alternate chemical method is needed.Gas chromatography/mass spectrometry (GC/MS) is the recommended confirmatory method."

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