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| Trade names | Antofin, Previsone, Pregno-Pan |
| Other names | Pregn-5-en-3β-ol-20-one 3β-acetate, Antofin, Artivis, Enescorb, Previsone, Sharmone, Pregnenolone-3-acetate, 1778-02-5, 3α-Acetoxy-5-pregnen-20-one, ZINC6304690, NSC 64827, Acetic acid 20-oxopregn-5-en-3alpha-yl ester[1] |
| Routes of administration | Topical |
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| ECHA InfoCard | 100.015.648 |
| Chemical and physical data | |
| Formula | C23H34O3 |
| Molar mass | 358.522 g·mol−1 |
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Pregnenolone acetate (brand namesAntofin,Previsone,Pregno-Pan), also known aspregn-5-en-3β-ol-20-one 3β-acetate, is asyntheticpregnanesteroid and anester ofpregnenolone which is described as aglucocorticoid and as askin-conditioning andskin anti-aging agent.[2][3] It has been reported to reducewrinkles in elderly women when applied in the form of a 0.5%topicalcream, effects which were suggested to be due to improvedhydration of theskin.[3] Pregnenolone acetate has been marketed inFrance in a topical cream containing 1% pregnenolone acetate and 10% "sex hormone" for the treatment of premature skin aging but was withdrawn from the market in 1992.[3] Although the medication has been described by some sources as a glucocorticoid, other authors have stated that systemic pregnenolone acetate has no undesirablemetabolic ortoxic effects even at high doses.[4]