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| Trade names | Acetoxanon, Acetoxanone, Acetoxy-Prenolon, Artisone, Artivis, Pregnartrone, Sterosone |
| Other names | 21-Hydroxypregnenolone 21-acetate; Pregnenolone 21-acetate; 21-Acetoxypregnenolone; A.O.P.; 3β,21-Dihydroxypregn-5-en-20-one 21-acetate; Pregn-5-en-3β,21-diol-20-one 21-acetate |
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| ECHA InfoCard | 100.008.454 |
| Chemical and physical data | |
| Formula | C23H34O4 |
| Molar mass | 374.521 g·mol−1 |
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Prebediolone acetate (brand namesAcetoxanon,Acetoxanone,Acetoxy-Prenolon,Artisone,Artivis,Pregnartrone,Sterosone), also known as21-hydroxypregnenolone 21-acetate or21-acetoxypregnenolone (A.O.P.), as well as3β,21-dihydroxypregn-5-en-20-one 21-acetate, is asyntheticpregnanesteroid which is described as aglucocorticoid and has been used in the treatment ofrheumatoid arthritis.[1][2][3] It is the C21acetateester ofprebediolone (21-hydroxypregnenolone), the C21hydroxylatedderivative ofpregnenolone.[1] Prebediolone acetate has been known since at least 1950.[4] The compound is also anintermediate in asynthesis ofdeoxycorticosterone acetate (21-acetoxyprogesterone).[5]
Artisone is a steroid of the 21-carbon type. It is 5-pregnene 3 beta, 21-dial-20-one 21 acetate.4 It is also known as 21-acetoxy-pregnenolone, acetoxanon, prebediolone acetate. It is an intermediate product in the synthesis of desoxycorticosterone acetate and is prepared by reacting 5,6-pregnene-3-ol-20-one with bromine and chloroform and treating the obtained oily bromide with potassium I acetate in alcohol.