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Polythiazide

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Polythiazide
Space-filling model of the polythiazide molecule
Clinical data
AHFS/Drugs.comMicromedex Detailed Consumer Information
MedlinePlusa601101
ATC code
Identifiers
  • 6-chloro-2-methyl-3-{[(2,2,2-trifluoroethyl)thio]methyl}-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
CAS Number
PubChemCID
IUPHAR/BPS
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.005.881Edit this at Wikidata
Chemical and physical data
FormulaC11H13ClF3N3O4S3
Molar mass439.87 g·mol−1
3D model (JSmol)
  • O=S(C1=CC(S(=O)(N(C(CSCC(F)(F)F)N2)C)=O)=C2C=C1Cl)(N)=O
 ☒NcheckY (what is this?)  (verify)

Polythiazide is athiazidediuretic.[1][2]

References

[edit]
  1. ^O'Brien ET, MacKinnon J (October 1972)."Propranolol and polythiazide in treatment of hypertension".British Heart Journal.34 (10):1042–4.doi:10.1136/hrt.34.10.1042.PMC 458544.PMID 5086971.
  2. ^Monroy A, Plata C, Hebert SC, Gamba G (July 2000). "Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: a new model for ions and diuretics interaction".American Journal of Physiology. Renal Physiology.279 (1): F161-9.doi:10.1152/ajprenal.2000.279.1.f161.PMID 10894798.
Na+-Cl
Na+-K+-Cl
Sulfonamides
(andetacrynic acid)
CA inhibitors (atPT)
Loop (Na-K-Cl atAL)
Thiazides (Na-Cl atDCT,
Calcium-sparing)
Thiazide-likes (primarilyDCT)
Potassium-sparing (atCD)
ESC blockers
Aldosterone antagonists
Osmotic diuretics (PT,DL)
Vasopressin receptor inhibitors
(DCT andCD)
Other
Combination products
Stub icon

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