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Inenzymology, apolyenoic fatty acid isomerase (EC5.3.3.13) is anenzyme thatcatalyzes thechemical reaction

(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate${\displaystyle \rightleftharpoons }$ (5Z,7E,9E,14Z,17Z)-icosapentaenoate

Hence, this enzyme has onesubstrate,(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate, and oneproduct,(5Z,7E,9E,14Z,17Z)-icosapentaenoate.

This enzyme belongs to the family ofisomerases, specifically those intramolecularoxidoreductases transposing C=C bonds. Thesystematic name of this enzyme class is(5Z,8Z,11Z,14Z,17Z)-icosapentaenoate Delta8,11-Delta7,9-isomerase (trans-double-bond-forming). Other names in common use includePFI,eicosapentaenoate cis-Delta5,8,11,14,17-eicosapentaenoate,cis-Delta5-trans-Delta7,9-cis-Delta14,17 isomerase,(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate Delta8,11-Delta7,8-isomerase,(incorrect),(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate Delta8,11-Delta7,9-isomerase, and(trans-double-bond-forming).

• Wise ML, Hamberg M,Gerwick WH (1994). "Biosynthesis of conjugated triene-containing fatty acids by a novel isomerase from the red marine alga Ptilota filicina".Biochemistry.33 (51):15223–32.doi:10.1021/bi00255a002.PMID 7803384.
• Wise ML, Soderstrom K, Murray TF,Gerwick WH (1996). "Synthesis and cannabinoid receptor binding activity of conjugated triene anandamide, a novel eicosanoid".Experientia.52 (1):88–92.doi:10.1007/BF01922423.PMID 8575565.
• Wise ML, Rossi J,Gerwick WH (1997). "Characterization of the substrate binding site of polyenoic fatty acid isomerase, a novel enzyme from the marine alga Ptilota filicina".Biochemistry.36 (10):2985–92.doi:10.1021/bi962158v.PMID 9062129.
• Zheng W, Wise ML, Wyrick A, Metz JG, Yuan L,Gerwick WH (2002). "Polyenoic fatty acid isomerase from the marine alga Ptilota filicina: protein characterization and functional expression of the cloned cDNA".Arch. Biochem. Biophys.401 (1):11–20.doi:10.1016/S0003-9861(02)00002-4.PMID 12054482.

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