During the late sixteenth and early seventeenth centuries, Poitou was a hotbed ofHuguenot (French Calvinist Protestant) activity among the nobility and bourgeoisie. The Protestants were discriminated against and brutally attacked during theFrench Wars of Religion (1562–1598). Under theEdict of Nantes, such discrimination was temporarily suspended but this measure was repealed by the French Crown.
Some of the French colonists, later known asAcadians, who settled beginning in 1604 in eastern North America came from southern Poitou. They established settlements in what is nowNova Scotia, and later inNew Brunswick—both of which were taken over in the later 18th century by the English, (after their 1763 victory in theSeven Years' War).
After the revocation of theEdict of Nantes in 1685, the French RomanCatholic Church conducted a strongCounter-Reformation effort. In 1793, this effort had contributed to the three-year-long open revolt against the French Revolutionary Government in the Bas-Poitou (Département ofVendée). Similarly, duringNapoleon'sHundred Days in 1815, the Vendée stayed loyal to the Restoration Monarchy of KingLouis XVIII. Napoleon dispatched 10,000 troops under GeneralJean Maximilien Lamarque topacify the region.
As noted by historian Andre Lampert:
"The persistent Huguenots of 17th Century Poitou and the fiercely Catholic rebellious Royalists of what came be the Vendée of the late 18th Century had ideologies very different, indeed diametrically opposed to each other. The common thread connecting both phenomena is a continuing assertion of a local identity and opposition to the central government inParis, whatever its composition and identity. (...) In the region whereLouis XIII andLouis XIV had encountered stiff resistance, theHouse of Bourbon gained loyal and militant supporters exactly when it had been overthrown and when a Bourbon loyalty came to imply a local loyalty in opposition to the new central government, that ofRobespierre."[5]
Large parts of theAngélique series of historical novels are set in 17th century Poitou.
InAlexandre Dumas'sThe Man in the Iron Mask, Aramis gives a romantic description of the marshes of Bas-Poitou as the most secluded place to lead a quiet life away from the perils of court.