Podocin is aprotein component of thefiltration slits ofpodocytes.Glomerular capillary endothelial cells, theglomerular basement membrane and the filtration slits function as the filtration barrier of thekidneyglomerulus.^[1]Mutations in the podocin geneNPHS2 can causenephrotic syndrome, such asfocal segmental glomerulosclerosis (FSGS) orminimal change disease (MCD).^[2] Symptoms may develop in the first few months of life (congenital nephrotic syndrome) or later in childhood.^[3]

Podocin is a membrane protein of theband-7-stomatinfamily, consisting of 383 amino acids. It has a transmembrane domain forming a hairpin structure, with two cytoplasmic ends at the N- and C-terminus, the latter of which interacts with the cytosolic tail ofnephrin, withCD2AP serving as an adaptor.^[4]

Podocin is localized on the membranes ofpodocyte foot processes (pedicels) where it oligomerizes inlipid rafts together withnephrin to form the filtration slits.^[4][5]

• Genes on human chromosome 1
• Proteins

• Protein pages needing a picture
• Human gene pages with Wikidata item