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Pitrazepin

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Pitrazepin
Clinical data
Pregnancy
category
  • ?
Routes of
administration		?
ATC code
  • none
Legal status
Legal status
  • In general: uncontrolled
Identifiers
  • 3-(piperazin-1-yl)-9H-dibenzo[c,f][1,2,4]triazolo[4,3-a]azepine
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC19H19N5
Molar mass317.396 g·mol−1
3D model (JSmol)
  • n4nc(N1CCNCC1)n5c2ccccc2Cc3ccccc3c45

Pitrazepin is acompetitiveGABAA andglycine receptorantagonist.[1][2][3] It has been used to studyinsect andsnailnervous systems inscientific research.[4][5][6][7][8][9]

CNS Rev:[10]

See also

[edit]

References

[edit]
  1. ^Gähwiler BH, Maurer R, Wüthrich HJ (April 1984). "Pitrazepin, a novel GABAA antagonist".Neuroscience Letters.45 (3):311–6.doi:10.1016/0304-3940(84)90244-1.PMID 6328380.S2CID 45153546.
  2. ^Braestrup C, Nielsen M (November 1985). "Interaction of pitrazepin with the GABA/benzodiazepine receptor complex and with glycine receptors".European Journal of Pharmacology.118 (1–2):115–21.doi:10.1016/0014-2999(85)90669-7.PMID 3002806.
  3. ^Curtis DR, Gynther BD (November 1986). "Pitrazepin: a central glycine and GABA antagonist".European Journal of Pharmacology.131 (2–3):311–3.doi:10.1016/0014-2999(86)90590-X.PMID 3816960.
  4. ^Anthony NM, Harrison JB, Sattelle DB (1993). "GABA Receptor molecules of insects".Comparative Molecular Neurobiology. Vol. 63. pp. 172–209.doi:10.1007/978-3-0348-7265-2_8.ISBN 978-3-0348-7267-6.PMID 7678525.
  5. ^Sattelle DB, Pinnock RD, Wafford KA, David JA (January 1988). "GABA receptors on the cell-body membrane of an identified insect motor neuron".Proceedings of the Royal Society B.232 (1269):443–56.Bibcode:1988RSPSB.232..443S.doi:10.1098/rspb.1988.0006.PMID 2451252.S2CID 40290279.
  6. ^Murphy VF, Wann KT (November 1988)."The action of GABA receptor agonists and antagonists on muscle membrane conductance in Schistocerca gregaria".British Journal of Pharmacology.95 (3):713–22.doi:10.1111/j.1476-5381.1988.tb11697.x.PMC 1854212.PMID 2850061.
  7. ^Zhang W, Han XY, Wong SM, Takeuchi H (January 1997). "Pharmacologic characteristics of excitatory gamma-amino-butyric acid (GABA) receptors in a snail neuron".General Pharmacology.28 (1):45–53.doi:10.1016/S0306-3623(96)00152-8.PMID 9112076.
  8. ^Kim KH, Takeuchi H (June 1990). "Pharmacological characteristics of two different types of inhibitory GABA receptors on Achatina fulica neurones".European Journal of Pharmacology.182 (1):49–62.doi:10.1016/0014-2999(90)90492-O.PMID 2169426.
  9. ^Takeuchi H (September 1992). "Sensitivities of Achatina giant neurones to putative amino acid neurotransmitters".Comparative Biochemistry and Physiology C.103 (1):1–12.doi:10.1016/0742-8413(92)90219-w.PMID 1360362.
  10. ^Demuro, A., Miledi, R. (December 2000). "Pitrazepin: Interactions with Transmitter Receptors of the Central and Peripheral Nervous Systems".CNS Drug Reviews.6 (4):290–302.doi:10.1111/j.1527-3458.2000.tb00154.x.
Ionotropic
GABAATooltip γ-Aminobutyric acid A receptor
GABAA-ρTooltip γ-Aminobutyric acid A-rho receptor
Metabotropic
GABABTooltip γ-Aminobutyric acid B receptor
Receptor
(ligands)
GlyRTooltip Glycine receptor
NMDARTooltip N-Methyl-D-aspartate receptor
Transporter
(blockers)
GlyT1Tooltip Glycine transporter 1
GlyT2Tooltip Glycine transporter 2
Classes
Antidepressants
(Tricyclic antidepressants(TCAs))
Antihistamines
Antipsychotics
Anticonvulsants
Anticholinergics
Others


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