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| Clinical data | |
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| Other names | 9-chloro-6-phenyl-2-prop-2-ynyl-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-3-one |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral |
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| Pharmacokinetic data | |
| Metabolism | Hepatic |
| Excretion | Renal |
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| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.052.650 |
| Chemical and physical data | |
| Formula | C18H13ClN2O |
| Molar mass | 308.77 g·mol−1 |
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Pinazepam (marketed under the brand nameDomar andDuna) is abenzodiazepine drug.[2] It possessesanxiolytic,anticonvulsant,sedative andskeletal muscle relaxant properties.[3]
Pinazepam and its metaboliteN-desmethyldiazepam are transferred to the developing fetusinutero, but the plasma drug level in the mother is usually significantly higher than in the fetus.[4]
Pinazepam differs from otherbenzodiazepines in that it has apropargyl group at theN-1 position of the benzodiazepine structure. It is less toxic than diazepam and in animal studies it appears to produce anxiolytic and anti-agitation properties with limitedhypnotic and motor coordination impairing properties.[5] Pinazepam is rapidly absorbed after oral administration. The main active metabolites of pinazepam are depropargylpinazepam (N-desmethyldiazepam,nordazepam) andoxazepam.[6] In humans pinazepam acts as a pure anxiolytic agent in that it does not possess to any significant degree the other pharmacological characteristics of benzodiazepines. Its lack of intellectual, motor and hypnotic impairing effects makes it more appropriate than other benzodiazepines for day time use.[7][8][9] The elimination half-life is longer in the elderly.[10]
