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| Trade names | Paredrinol, Presoitan, Pulsotyl, Veritain, Veritol |
| Other names | 4-Hydroxy-N-methylamphetamine; 4-HMA; 4-Hydroxymethamphetamine;para-Hydroxymethamphetamine; PHMA; Hydroxymethamphetamine |
| Routes of administration | Topical (ocular) |
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| ECHA InfoCard | 100.006.114 |
| Chemical and physical data | |
| Formula | C10H15NO |
| Molar mass | 165.236 g·mol−1 |
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Pholedrine, also known as4-hydroxy-N-methylamphetamine and sold under the brand namesParedrinol,Pulsotyl, andVeritol among others, is asympathomimeticdrug used intopicaleye drops todilate the pupil.[1][2][3] It can be used to diagnoseHorner's syndrome.[3]
In 2004, it remained marketed only inGermany.[1]
Pholedrine is described as asympathomimetic,antihypotensive, andephedrine-like agent.[4][1][5]
Pholedrine, also known as 4-hydroxy-N-methylamphetamine, is asubstituted phenethylamine andamphetaminederivative.[4][1] It isstructurally related tomethamphetamine (N-methylamphetamine),norpholedrine (4-hydroxyamphetamine),oxilofrine (4,β-dihydroxy-N-methylamphetamine), andtyramine (4-hydroxyphenethylamine).
It is usedpharmaceutically as thesulfatesalt.[1][4]
The predictedlog P of pholedrine ranges from 1.12 to 1.7.[2][6][7]
Pholedrine wassynthesized by 1951.[4]
Pholedrine is thegeneric name of the drug and itsINNTooltip International Nonproprietary Name,BANTooltip British Approved Name, andDCFTooltip Dénomination Commune Française, whilefoledrina is itsDCITTooltip Denominazione Comune Italiana.[4][1][5] The drug has been sold under brand names includingPholedrin Liquidum,Pholedrin-Longo-Isis,Presoitan,Veritain, andVeritol among others.[4][1]
Pholedrine (4-hydroxymethamphetamine) is also a majormetabolite ofmethamphetamine.
