Phenolates (also calledphenoxides) areanions,salts, and esters ofphenols, containing the phenolate ion. They may be formed by reaction of phenols with strong base.[1]
Alkali metal phenolates, such assodium phenolate hydrolyze in aqueous solution to form basic solutions.[2] At pH = 10, phenol and phenolate are in approximately 1:1 proportions.
The phenoxide anion (akaphenolate) is a strongnucleophile with a comparable to the one of carbanions or tertiary amines.[3] Generally, oxygen attack of phenoxide anions is kinetically favored, while carbon-attack is thermodynamically preferred (seeThermodynamic versus kinetic reaction control). Mixed oxygen/carbon attack and by this a loss of selectivity is usually observed if the reaction rate reaches diffusion control.[4]
Alkyl aryl ethers can be synthesized through theWilliamson ether synthesis by treating sodium phenolate with analkyl halide:[5]
Salicylic acid is produced in theKolbe–Schmitt reaction between carbon dioxide and sodium phenolate.
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