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Phenglutarimide

From Wikipedia, the free encyclopedia

Chemical compound

Pharmaceutical compound

Phenglutarimide
Clinical data

ATC code	N04AA09 (WHO)
Identifiers
IUPAC name 3-(2-Diethylaminoethyl)-4-phenylpiperidine-2,6-dione
CAS Number	1156-05-4^N
PubChemCID	102669
ChemSpider	92737^Y
UNII	679RC9H8TG
KEGG	D07301^Y
ChEMBL	ChEMBL1096643^Y
CompTox Dashboard(EPA)	DTXSID0023450
ECHA InfoCard	100.013.261
Chemical and physical data
Formula	C₁₇H₂₄N₂O₂
Molar mass	288.391 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCN(CC)CC[C@]1(CCC(=O)NC1=O)c1ccccc1
InChI InChI=1S/C17H24N2O2/c1-3-19(4-2)13-12-17(14-8-6-5-7-9-14)11-10-15(20)18-16(17)21/h5-9H,3-4,10-13H2,1-2H3,(H,18,20,21)^Y Key:BFMBKRQFMIILCH-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)

Phenglutarimide (brand namesAturbal andAturbane) is ananticholinergic used^{[citation needed]} as anantiparkinsonian agent.^[1]

References

^Battegay R (July 1958). "[Aturban (phenglutarimide), a new therapeutic drug for parkinsonism; comparative investigation on the therapy of parkinsonism]".Schweizerische Medizinische Wochenschrift (in German).88 (30):740–2.PMID 13580191.

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Antiparkinson agents (N04)

DA precursors	Levodopa^# (+benserazide,+carbidopa,+carbidopa/entacapone) Foslevodopa (+foscarbodipa) Melevodopa (+carbidopa)
DA receptor agonists	Ergoline:Bromocriptine Cabergoline Dihydroergocryptine Lisuride Pergolide Non-ergoline:Apomorphine Piribedil Pramipexole Ropinirole Rotigotine Talipexole
MAO-B inhibitors	Rasagiline Safinamide Selegiline
COMT inhibitors	Entacapone Opicapone Tolcapone
AAAD inhibitors	Benserazide (+levodopa) Carbidopa^# (+carbidopa,+melevodopa,+carbidopa/entacapone) Foscarbidopa (+foslevodopa)

Anticholinergics

Others

Adamantanes (e.g.,amantadine,memantine,rimantadine)
Adenosine receptor antagonists (e.g.,caffeine,istradefylline)
Budipine

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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Muscarinic acetylcholine receptor modulators

mAChRsTooltip Muscarinic acetylcholine receptors

Precursors
(andprodrugs)

See also: Receptor/signaling modulators; Nicotinic acetylcholine receptor modulators; Acetylcholine metabolism/transport modulators

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