 | |
| Clinical data | |
|---|---|
| Trade names | Antergan |
| Other names | RP-2339 |
| Drug class | Antihistamine;H1 receptor antagonist |
| Identifiers | |
| |
| CAS Number |
|
| PubChemCID | |
| ChemSpider |
|
| UNII | |
| CompTox Dashboard(EPA) | |
| Chemical and physical data | |
| Formula | C17H22N2 |
| Molar mass | 254.377 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
Phenbenzamine, sold under the brand nameAntergan and known by the former developmental code nameRP-2339, is anantihistamine of theethylenediamine class which also hasanticholinergic properties.[1][2] It was introduced in 1941 or 1942 and was the first antihistamine to be introduced for medical use.[3][4][5] Soon following its introduction, phenbenzamine was replaced by another antihistamine of the same class known asmepyramine (pyrilamine; Neoantergan).[5][6] Following this, other antihistamines, such asdiphenhydramine,promethazine, andtripelennamine, were developed and introduced.[5][7] Owing to theirsedative effects, phenbenzamine and promethazine were assessed in the treatment ofmanic depression inFrance in the 1940s and were regarded as promising therapies for such purposes.[3] Whereas phenbenzamine was the first clinically useful antihistamine,piperoxan was the first compound with antihistamine properties to be discovered and was synthesized in the early 1930s.[7]
Phenbenzamine can be prepared by the reaction ofN-benzylaniline with 2-chloroethyldimethylamine.[8][9]
 | Thisdrug article relating to therespiratory system is astub. You can help Wikipedia byadding missing information. |
