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| Routes of administration | ? |
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| ECHA InfoCard | 100.004.517 |
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| Formula | C17H26N2O |
| Molar mass | 274.408 g·mol−1 |
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Phenampromide[2] is anopioidanalgesic from the ampromide family of drugs, related to other drugs such aspropiram anddiampromide. It was invented in the 1960s[3] byAmerican Cyanamid Co. Although never given a general release, it was research found that 60 mg of phenampromide is equivalent to about 50 mg of codeine. Tests on its twoenantiomers showed that all of the analgesic effects were caused by the (S)-isomer. Introduction of a phenyl group to the 4-position of the piperidine-ring produces a drug 60-fold more potent than morphine.[4] The most potent reported derivative is 4-hydroxy-4-phenyl phenapromide which displays analgesic activity some x150 greater than morphine.[5]
Phenampromide produces similar effects to fentanyl, includinganalgesia,sedation,dizziness andnausea.
Phenampromide is in Schedule I of the Controlled Substances Act 1970 of the United States as a narcotic with ACSCN 9638 with a zero aggregate manufacturing quota as of 2014. The free base conversion ratio for salts includes 0.88 for the hydrochloride.[8] It is listed under the Single Convention for the Control of Narcotic Substances 1961 and is controlled in most countries in the same fashion as fentanyl.