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| Other names | α-Methylaminovalerophenone; α-Propyl-β-keto-N-methylphenethylamine; α-Desmethyl-α-propyl-N-methylcathinone; α-Desmethyl-α-propylmethcathinone; α-Desmethyl-α-propyl-β-keto-N-methylamphetamine; α-Desmethyl-α-propyl-β-ketomethamphetamine |
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| ECHA InfoCard | 100.231.338 |
| Chemical and physical data | |
| Formula | C12H17NO |
| Molar mass | 191.274 g·mol−1 |
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Pentedrone (also known asα-methylaminovalerophenone) is astimulant of thecathinone class that has been sold as adesigner drug and has been found since 2010 as an ingredient in a number of "bath salt" mixes sold as legal highs.[3][4][5][6][7][8][9]
Pentedrone acts as anorepinephrine-dopamine reuptake inhibitor (NDRI) without inducingmonoamine release, a similarmechanism of action tomethylphenidate.[10][11] ItsIC50Tooltip half-maximal inhibitory concentration values forinhibition of monoamine reuptake have been reported to be 610 nM fornorepinephrine, 2,500 μM fordopamine, and 135,000 μM forserotonin.[10] In rodents, pentedrone has been found to produceconditioned place preference (CPP), to beself-administered, and todose-dependentlystimulate locomotor activity.[11] Hence, pentedrone showspsychostimulant-like andreinforcing effects in animals.[11]
Pentedrone has been linked to at least one death where it was combined withα-PVP and caused heart failure.[12]
A forensic standard of pentedrone is available, and the compound has been posted on the Forendex website of potential drugs of abuse.[13]
On January 28, 2014, the DEA listed it, along with nine other synthetic cathinones, on the Schedule 1 with a temporary ban, effective February 27, 2014.[14]
Pentedrone is anAnlage II controlled drug in Germany.
As of October 2015 Pentedrone is a controlled substance in China.[15]
Pentedrone is banned in the Czech Republic.[16]
Pentedrone is banned in the Slovak Republic.[17]