The protein encoded by this gene is a member of theG protein-coupled receptor family 2. This protein is a receptor forparathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone 1 receptor (PTH1R). It is activated by PTH but not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in the brain and pancreas.[5]
The molecular interaction of the PTH2 receptor with thepeptideTIP39 has been characterized in full 3D molecular detail, identifying among other residues Tyr-318 intransmembrane helix 5 as a key residue for high affinity binding.[6]
Usdin TB, Modi W, Bonner TI (October 1996). "Assignment of the human PTH2 receptor gene (PTHR2) to chromosome 2q33 by fluorescence in situ hybridization".Genomics.37 (1):140–141.doi:10.1006/geno.1996.0532.PMID8921382.
Seeliger S, Hausberg M, Eue I, Usdin T, Rahn KH, Kosch M (June 2003). "The parathyroid hormone-2 receptor is expressed on human leukocytes and down-regulated in hyperparathyroidism".Clinical Nephrology.59 (6):429–435.doi:10.5414/CNP59429.PMID12834174.
"Parathyroid Hormone Receptors: PTH2".IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived fromthe original on 2016-03-03. Retrieved2008-12-09.
