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| ECHA InfoCard | 100.005.657 |
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| Formula | C10H14NO6P |
| Molar mass | 275.197 g·mol−1 |
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Paraoxon is aparasympathomimetic drug which acts as ancholinesterase inhibitor. It is anorganophosphateoxon, and the activemetabolite of the insecticideparathion. It is also used as anophthalmological drug againstglaucoma. Paraoxon is one of the most potent acetylcholinesterase-inhibitinginsecticides available, around 70% as potent as the nerve agentsarin, and so is now rarely used as an insecticide due to the risk ofpoisoning to humans and other animals. Paraoxon has been used by scientists to study acute and chronic effects of organophosphate intoxication.[1][2] It is easily absorbed through skin, and was allegedly used as anassassination weapon by the apartheid-eraSouth Africanchemical weapons programProject Coast.[3]
EA-1370 is a phosphonate analogue, isopropyl para-nitrophenyl methylphosphonate, the junction of the nerve agent sarin with the leaving group of paraoxon.[4] Contact with the fluoride ion in a polar-aprotic solvent regenerates it to sarin.[5][6]
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