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Papaveretum

From Wikipedia, the free encyclopedia
Chemical compound

Pharmaceutical compound
Papaveretum
Combination of
MorphineOpioid analgesic
PapaverineAntispasmodic
CodeineOpioid analgesic
Clinical data
Trade namesOmnopon
ATC code
Identifiers
CAS Number
PubChemCID

Papaveretum (BAN) is a preparation containing a mixture ofhydrochloride salts ofopiumalkaloids.[1] Since 1993, papaveretum has been defined in theBritish Pharmacopoeia (BP) as a mixture of 253 partsmorphine hydrochloride, 23 partspapaverine hydrochloride, and 20 partscodeine hydrochloride.[2] It is commonly marketed to medical agencies under thetrade nameOmnopon.

Although the use of papaveretum is now relatively uncommon following the wide availability of single-componentopiates and syntheticopioids (e.g.pethidine), it is still used to relieve moderate to severe pain and for pre-operative sedation. In clinical settings, papaveretum is usually administered to patients viasubcutaneous,intramuscular, orintravenous routes. Additionally, the morphinesyrettes found in combat medical kits issued to military personnel actually contain Omnopon.

Prior to 1993, papaveretum also containednoscapine, though this component was removed from the BP formulation due to thegenotoxic potential of noscapine.

References

[edit]
  1. ^Lewis KE (2002)."Analgesic Drugs". In Pinnock C, Lin T, Smith T, Jones R (eds.).Fundamentals of Anaesthesia (2nd ed.). Cambridge University Press. p. 626.ISBN 978-1-84110-122-4.
  2. ^Sweetman SC, ed. (November 30, 2004).Martindale: The complete drug reference (34th ed.). London: Pharmaceutical Press.ISBN 0-85369-550-4.
μ-opioid
(MOR)
Agonists
(abridged;
full list)
Antagonists
δ-opioid
(DOR)
Agonists
Antagonists
κ-opioid
(KOR)
Agonists
Antagonists
Nociceptin
(NOP)
Agonists
Antagonists
Others


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