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Poliovirus receptor-related 1

From Wikipedia, the free encyclopedia
(Redirected fromPVRL1)
Protein-coding gene in the species Homo sapiens
"hveC" redirects here. For Harbourview Estates C, seeCityPlace, Toronto.

NECTIN1
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

3ALP,3SKU,3U83,4FMF,4MYW

Identifiers
AliasesNECTIN1, CD111, CLPED1, ED4, HIgR, HV1S, HVEC, OFC7, PRR, PRR1, PVRR, PVRR1, SK-12, nectin-1, PVRL1, nectin cell adhesion molecule 1
External IDsOMIM:600644;MGI:1926483;HomoloGene:2138;GeneCards:NECTIN1;OMA:NECTIN1 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for NECTIN1
Genomic location for NECTIN1
Band11q23.3Start119,623,408bp[1]
End119,729,200bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for NECTIN1
Genomic location for NECTIN1
Band9|9 A5.1Start43,655,281bp[2]
End43,743,955bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of abdomen

  • skin of leg

  • nipple

  • mucosa of pharynx

  • body of tongue

  • gingival epithelium

  • lateral nuclear group of thalamus

  • subthalamic nucleus

  • vulva

  • external globus pallidus
Top expressed in
  • lip

  • neural layer of retina

  • molar

  • dentate gyrus of hippocampal formation granule cell

  • visual cortex

  • epiblast

  • primary visual cortex

  • decidua

  • genital tubercle

  • cerebellar cortex
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5818

58235

Ensembl

ENSG00000110400

ENSMUSG00000032012

UniProt

Q15223

Q9JKF6

RefSeq (mRNA)

NM_203286
NM_002855
NM_032767
NM_203285

NM_021424

RefSeq (protein)

NP_002846
NP_976030
NP_976031

NP_067399

Location (UCSC)Chr 11: 119.62 – 119.73 MbChr 9: 43.66 – 43.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Poliovirus receptor-related 1 (PVRL1), also known asnectin-1 andCD111 (formerlyherpesvirus entry mediator C,HVEC) is a human protein of theimmunoglobulin superfamily (IgSF), also considered a member of thenectins.[5] It is a membrane protein with three extracellular immunoglobulin domains, a single transmembrane helix and a cytoplasmic tail. The protein can mediateCa2+-independentcellular adhesion further characterizing it as IgSF cell adhesion molecule (IgSF CAM).

Function

[edit]

PVRL1 is an adhesion molecule found in a wide range of tissues where it localizes in various junctions such as theadherens junction ofepithelial tissue or thechemical synapse ofneurons. The cytoplasmic tail of PVRL1 can bind the proteinafadin which is a scaffolding protein that bindsactin.

In the chemical synapse PVRL1 interacts withPVRL3 (nectin-3) and both proteins can be found in neuronal tissue already in early stages of brain development as well as in aging brains. The two proteins have been found to localize asymmetrically along the chemical synapse, with PVRL1 primarily on theaxonal side and PVRL3 on thedendritic side.

The protein has been revealed as one of the key players in mediating cellular entry of theHerpes simplex virus by interacting with the viral glycoprotein D (gD).[6]

See also

[edit]

Interactions

[edit]

PVRL1 has been shown tointeract withMLLT4.[7]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000110400Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000032012Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^"Entrez Gene: PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin)".
  6. ^Cocchi F, Lopez M, Menotti L, Aoubala M, Dubreuil P, Campadelli-Fiume G (1999)."The V domain of herpesvirus Ig-like receptor (HIgR) contains a major functional region in herpes simplex virus-1 entry into cells and interacts physically with the viral glycoprotein D".Proc. Natl. Acad. Sci. U.S.A.95 (26):15700–5.doi:10.1073/pnas.95.26.15700.PMC 28107.PMID 9861033.
  7. ^Takahashi K, Nakanishi H, Miyahara M, Mandai K, Satoh K, Satoh A, Nishioka H, Aoki J, Nomoto A, Mizoguchi A, Takai Y (May 1999)."Nectin/PRR: An Immunoglobulin-like Cell Adhesion Molecule Recruited to Cadherin-based Adherens Junctions through Interaction with Afadin, a PDZ Domain–containing Protein".J. Cell Biol.145 (3):539–49.doi:10.1083/jcb.145.3.539.PMC 2185068.PMID 10225955.

Further reading

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External links

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

1–50
51–100
101–150
151–200
201–250
251–300
301–350
Calcium-independent
IgSF CAM
Integrins
Calcium-dependent
Cadherins
Classical
Desmosomal
Protocadherin
Unconventional/ungrouped
Selectins
Other


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