PTPRJ, CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1, protein tyrosine phosphatase, receptor type J, protein tyrosine phosphatase receptor type J, R-PTP-J, HPTP eta
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This PTP is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 (PLCG1) and Linker for Activation of T Cells (LAT). This PTP was also found to dephosphorylate PDGF beta receptor, and may be involved in UV-induced signal transduction.[7]
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Autschbach F, Palou E, Mechtersheimer G, Rohr C, Pirotto F, Gassler N, Otto HF, Schraven B, Gaya A (2000). "Expression of the membrane protein tyrosine phosphatase CD148 in human tissues".Tissue Antigens.54 (5):485–98.doi:10.1034/j.1399-0039.1999.540506.x.PMID10599888.
Billard C, Delaire S, Raffoux E, Bensussan A, Boumsell L (2000). "Switch in the protein tyrosine phosphatase associated with human CD100 semaphorin at terminal B-cell differentiation stage".Blood.95 (3):965–72.doi:10.1182/blood.V95.3.965.003k39_965_972.PMID10648410.
Ruivenkamp CA, van Wezel T, Zanon C, Stassen AP, Vlcek C, Csikós T, Klous AM, Tripodis N, Perrakis A, Boerrigter L, Groot PC, Lindeman J, Mooi WJ, Meijjer GA, Scholten G, Dauwerse H, Paces V, van Zandwijk N, van Ommen GJ, Demant P (2002). "Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers".Nat. Genet.31 (3):295–300.doi:10.1038/ng903.PMID12089527.S2CID12338558.
Holsinger LJ, Ward K, Duffield B, Zachwieja J, Jallal B (2002). "The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)".Oncogene.21 (46):7067–76.doi:10.1038/sj.onc.1205858.PMID12370829.S2CID25745858.
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Dong HY, Shahsafaei A, Dorfman DM (2003). "CD148 and CD27 are expressed in B cell lymphomas derived from both memory and naïve B cells".Leuk. Lymphoma.43 (9):1855–8.doi:10.1080/1042819021000006385.PMID12685844.S2CID37520677.
