Receptor-type tyrosine-protein phosphatase H is anenzyme that in humans is encoded by thePTPRHgene.[5][6]
The protein encoded by this gene is a member of the proteintyrosine phosphatase (PTP) family. PTPs are known to besignaling molecules that regulate a variety of cellular processes includingcell growth,differentiation,mitotic cycle, and oncogenic transformation. This PTP possesses anextracellular region, a single transmembrane region, and a singleintracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eightfibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues.[6]
Marneros AG, Mehenni H, Reichenberger E, et al. (2001). "Gene for the human transmembrane-type protein tyrosine phosphatase H (PTPRH): genomic structure, fine-mapping and its exclusion as a candidate for Peutz-Jeghers syndrome".Cytogenet. Cell Genet.92 (3–4):213–6.doi:10.1159/000056905.PMID11435690.S2CID20187527.
Nagano H, Noguchi T, Inagaki K, et al. (2003). "Downregulation of stomach cancer-associated protein tyrosine phosphatase-1 (SAP-1) in advanced human hepatocellular carcinoma".Oncogene.22 (30):4656–63.doi:10.1038/sj.onc.1206588.PMID12879010.S2CID2707273.
