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PTPN9

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
PTPN9
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

2PA5,4GE2,4GE5,4GE6,4ICZ

Identifiers
AliasesPTPN9, MEG2, PTPMEG2, protein tyrosine phosphatase, non-receptor type 9, protein tyrosine phosphatase non-receptor type 9
External IDsOMIM:600768;MGI:1928376;HomoloGene:2121;GeneCards:PTPN9;OMA:PTPN9 - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for PTPN9
Genomic location for PTPN9
Band15q24.2Start75,463,251bp[1]
End75,579,315bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for PTPN9
Genomic location for PTPN9
Band9|9 BStart56,902,207bp[2]
End56,970,091bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • ganglionic eminence

  • stromal cell of endometrium

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • tibial nerve

  • monocyte

  • hair follicle

  • islet of Langerhans

  • rectum
Top expressed in
  • entorhinal cortex

  • perirhinal cortex

  • lactiferous gland

  • choroid plexus of fourth ventricle

  • Ileal epithelium

  • CA3 field

  • corneal stroma

  • maxillary prominence

  • Gonadal ridge

  • mandibular prominence
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5780

56294

Ensembl

ENSG00000169410

ENSMUSG00000032290

UniProt

P43378

O35239

RefSeq (mRNA)

NM_002833

NM_019651

RefSeq (protein)

NP_002824

NP_062625

Location (UCSC)Chr 15: 75.46 – 75.58 MbChr 9: 56.9 – 56.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 9 is anenzyme that in humans is encoded by thePTPN9gene.[5][6]

Function

[edit]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes includingcell growth,differentiation,mitotic cycle, andoncogenic transformation. This PTP contains anN-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through theGolgi complex in yeast. This PTP was found to be activated by poly-phosphoinositide, and is thought to be involved in signaling events regulatingphagocytosis.[6]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000169410 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000032290 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Gu M, Warshawsky I, Majerus PW (May 1992)."Cloning and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to retinaldehyde-binding protein and yeast SEC14p".Proc Natl Acad Sci U S A.89 (7):2980–4.Bibcode:1992PNAS...89.2980G.doi:10.1073/pnas.89.7.2980.PMC 48787.PMID 1557404.
  6. ^ab"Entrez Gene: PTPN9 protein tyrosine phosphatase, non-receptor type 9".

Further reading

[edit]

External links

[edit]
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Tyrosine-protein phosphatase non-receptor type 9 (PTPN9)


PDB gallery
  • 2pa5: Crystal structure of human protein tyrosine phosphatase PTPN9
    2pa5: Crystal structure of human protein tyrosine phosphatase PTPN9
Class I
Classical PTPs
Receptor type PTPs
Non receptor type PTPs
VH1-like or
dual specific
phosphatases
(DSPs)
MAPK phosphatases (MKPs)
Slingshots
PRLs
CDC14s
Atypical DSPs
Phosphatase and tensin
homologs (PTENs)
Myotubularins
Class II
Class III
Class IV


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