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PSNCBAM-1

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
PSNCBAM-1
Identifiers
  • 1-(4-chlorophenyl)-3-(3-(6-(pyrrolidin-1-yl)pyridin-2-yl)phenyl)urea
CAS Number
PubChemCID
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC22H21ClN4O
Molar mass392.89 g·mol−1
3D model (JSmol)
  • Clc1ccc(NC(=O)Nc2cccc(c2)c3cccc(n3)N4CCCC4)cc1
  • InChI=1S/C22H21ClN4O/c23-17-9-11-18(12-10-17)24-22(28)25-19-6-3-5-16(15-19)20-7-4-8-21(26-20)27-13-1-2-14-27/h3-12,15H,1-2,13-14H2,(H2,24,25,28)
  • Key:HDAYFSFWIPRJSO-UHFFFAOYSA-N

PSNCBAM-1 is a negativeallosteric modulator of thecannabinoidCB1receptor.[1][2]

See also

[edit]

References

[edit]
  1. ^German N, Decker AM, Gilmour BP, Gay EA, Wiley JL, Thomas BF, Zhang Y (September 2014)."Diarylureas as Allosteric Modulators of the Cannabinoid CB1 Receptor: Structure–Activity Relationship Studies on 1-(4-Chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1)".Journal of Medicinal Chemistry.57 (18):7758–7769.doi:10.1021/jm501042u.PMC 4175001.PMID 25162172.
  2. ^Horswill JG, Bali U, Shaaban S, Keily JF, Jeevaratnam P, Babbs AJ, Reynet C, Wong Kai In P (November 2007)."PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats".British Journal of Pharmacology.152 (5):805–814.doi:10.1038/sj.bjp.0707347.PMC 2190018.PMID 17592509.
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AllostericCBRTooltip Cannabinoid receptorligands
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  • Others:2-PG(directly potentiates activity of 2-AG at CB1 receptor)
  • ARN-272(FAAH-like anandamide transporter inhibitor)
See also
Receptor/signaling modulators
Cannabinoids (cannabinoids by structure)


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