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| Formula | C26H32O4 |
| Molar mass | 408.538 g·mol−1 |
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PSB-SB-487 is an experimental drug which is used as a pharmacological research tool. It is acoumarin derivative which is an antagonist at the formerorphan receptorGPR55. Unlike older GPR55 antagonists such asO-1918, PSB-SB-487 has good selectivity over the related receptorGPR18, with an IC50 of 113nM at GPR55 vs 12500nM at GPR18.[1] However it has poorer selectivity over other related receptors, acting as a weak antagonist atCB1 with a Ki of 1170nM, and a partial agonist atCB2 with a Ki of 292nM.[2]
