The DNA-associated protein encoded by this gene is a member of the paired family ofhomeobox proteins localized to the nucleus. The protein functions as atranscription coactivator, enhancing the DNA-binding activity ofserum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates musclecreatine kinase, indicating a role in the establishment of diversemesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns.[6]
^Nohno T, Koyama E, Myokai F, Taniguchi S, Ohuchi H, Saito T, Noji S (July 1993). "A chicken homeobox gene related to Drosophila paired is predominantly expressed in the developing limb".Dev. Biol.158 (1):254–64.doi:10.1006/dbio.1993.1184.PMID8101172.
^Cserjesi P, Lilly B, Bryson L, Wang Y, Sassoon DA, Olson EN (August 1992). "MHox: a mesodermally restricted homeodomain protein that binds an essential site in the muscle creatine kinase enhancer".Development.115 (4):1087–101.doi:10.1242/dev.115.4.1087.PMID1360403.
^ten Berge D, Brouwer A, Korving J, Martin JF, Meijlink F (October 1998). "Prx1 and Prx2 in skeletogenesis: roles in the craniofacial region, inner ear and limbs".Development.125 (19):3831–42.doi:10.1242/dev.125.19.3831.hdl:1969.1/184321.PMID9729491.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".Gene.138 (1–2):171–4.doi:10.1016/0378-1119(94)90802-8.PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene.200 (1–2):149–56.doi:10.1016/S0378-1119(97)00411-3.PMID9373149.
Nakamura T, Yamazaki Y, Hatano Y, Miura I (1999). "NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15)".Blood.94 (2):741–7.doi:10.1182/blood.V94.2.741.PMID10397741.
Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A (February 2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages".Nat. Med.9 (2):191–7.doi:10.1038/nm822.PMID12539042.S2CID26145639.
