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PRPF6

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
PRPF6
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

3JCR

Identifiers
AliasesPRPF6, ANT-1, ANT1, C20orf14, Prp6, RP60, SNRNP102, TOM, U5-102K, hPrp6, pre-mRNA processing factor 6
External IDsOMIM:613979;MGI:1922946;HomoloGene:5368;GeneCards:PRPF6;OMA:PRPF6 - orthologs
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for PRPF6
Genomic location for PRPF6
Band20q13.33Start63,981,132bp[1]
End64,033,100bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for PRPF6
Genomic location for PRPF6
Band2|2 H4Start181,233,661bp[2]
End181,297,453bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tendon of biceps brachii

  • paraflocculus of cerebellum

  • beta cell

  • right hemisphere of cerebellum

  • ganglionic eminence

  • right uterine tube

  • ventricular zone

  • skin of leg

  • Achilles tendon

  • popliteal artery
Top expressed in
  • supraoptic nucleus

  • aortic valve

  • ascending aorta

  • Rostral migratory stream

  • fossa

  • condyle

  • internal carotid artery

  • external carotid artery

  • zygote

  • primary oocyte
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

24148

68879

Ensembl

ENSG00000101161

ENSMUSG00000002455

UniProt

O94906

Q91YR7

RefSeq (mRNA)

NM_012469

NM_133701

RefSeq (protein)

NP_036601

NP_598462

Location (UCSC)Chr 20: 63.98 – 64.03 MbChr 2: 181.23 – 181.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pre-mRNA-processing factor 6 is aprotein that in humans is encoded by thePRPF6gene.[5][6][7]

The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing.[7]

Interactions

[edit]

PRPF6 has been shown tointeract withTXNL4B,[8]ARAF[9][10] andAndrogen receptor.[11]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000101161 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000002455 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Nishikimi A, Mukai J, Kioka N, Yamada M (January 2000). "A novel mammalian nuclear protein similar to Schizosaccharomyces pombe Prp1p/Zer1p and Saccharomyces cerevisiae Prp6p pre-mRNA splicing factors".Biochim Biophys Acta.1435 (1–2):147–52.doi:10.1016/s0167-4838(99)00203-4.PMID 10561546.
  6. ^Makarov EM, Makarova OV, Achsel T, Luhrmann R (June 2000). "The human homologue of the yeast splicing factor prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions".J Mol Biol.298 (4):567–75.doi:10.1006/jmbi.2000.3685.PMID 10788320.
  7. ^ab"Entrez Gene: PRPF6 PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)".
  8. ^Sun, Xiaojing; Zhang Hua; Wang Dan; Ma Dalong; Shen Yan; Shang Yongfeng (July 2004)."DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression".J. Biol. Chem.279 (31). United States:32839–47.doi:10.1074/jbc.M402522200.ISSN 0021-9258.PMID 15161931.
  9. ^Yuryev, Anton; Wennogle Lawrence P (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis".Genomics.81 (2). United States:112–25.doi:10.1016/S0888-7543(02)00008-3.ISSN 0888-7543.PMID 12620389.
  10. ^Yuryev, A; Ono M; Goff S A; Macaluso F; Wennogle L P (July 2000)."Isoform-specific localization of A-RAF in mitochondria".Mol. Cell. Biol.20 (13). UNITED STATES:4870–8.doi:10.1128/MCB.20.13.4870-4878.2000.ISSN 0270-7306.PMC 85938.PMID 10848612.
  11. ^Zhao, Yue; Goto Kiminobu; Saitoh Masayuki; Yanase Toshihiko; Nomura Masatoshi; Okabe Taijiro; Takayanagi Ryoichi; Nawata Hajime (August 2002)."Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor".J. Biol. Chem.277 (33). United States:30031–9.doi:10.1074/jbc.M203811200.ISSN 0021-9258.PMID 12039962.

Further reading

[edit]

External links

[edit]
Nuclear
RNA splicing
pre-mRNA factors
Cytosolic
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