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PRPF4

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

PRPF4

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
1MZW,3JCR

Identifiers

Aliases

PRPF4, HPRP4, HPRP4P, PRP4, Prp4p, RP70, SNRNP60, pre-mRNA processing factor 4

External IDs

OMIM:607795;MGI:1917302;HomoloGene:3446;GeneCards:PRPF4;OMA:PRPF4 - orthologs

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	9q32	Start	113,275,642bp^[1]
Band	9q32	End	113,294,009bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4\|4 B3	Start	62,327,034bp^[2]
Band	4\|4 B3	End	62,345,227bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

secondary oocyte

corpus epididymis

cartilage tissue

endothelial cell

islet of Langerhans

tail of epididymis

caput epididymis

embryo

Skeletal muscle tissue of biceps brachii

ventricular zone

Top expressed in

hand

maxillary prominence

epiblast

mandibular prominence

foot

yolk sac

interventricular septum

primitive streak

cumulus cell

superior cervical ganglion

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	U4 snRNA binding protein binding U6 snRNA binding
Cellular component	Cajal body nuclear speck spliceosomal complex spliceosomal snRNP complex U4/U6 snRNP nucleoplasm U4/U6 x U5 tri-snRNP complex nucleus U2-type precatalytic spliceosome
Biological process	RNA splicing, via transesterification reactions mRNA processing RNA processing RNA splicing mRNA splicing, via spliceosome
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


9128


70052

Ensembl


ENSG00000136875


ENSMUSG00000066148

UniProt


O43172


Q9DAW6

RefSeq (mRNA)


NM_001244926 NM_004697 NM_001322266 NM_001322267


NM_027297

RefSeq (protein)


NP_001231855 NP_001309195 NP_001309196 NP_004688


NP_081573

Location (UCSC)

Chr 9: 113.28 – 113.29 Mb

Chr 4: 62.33 – 62.35 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

U4/U6 small nuclear ribonucleoprotein Prp4 is aprotein that is found in humans and encoded by thePRPF4gene.^[5]^[6]^[7]

The removal ofintrons from nuclear pre-mRNAs occurs on complexes calledspliceosomes, which are made up of 4small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors.

PRPF4 is 1 of several proteins that associates with U4 and U6 snRNPs.[supplied byOMIM]^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000136875 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000066148 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lauber J, Plessel G, Prehn S, Will CL, Fabrizio P, Groning K, Lane WS, Luhrmann R (Sep 1997)."The human U4/U6 snRNP contains 60 and 90kD proteins that are structurally homologous to the yeast splicing factors Prp4p and Prp3p".RNA.3 (8):926–41.PMC 1369537.PMID 9257651.
^Horowitz DS, Kobayashi R, Krainer AR (Dec 1997)."A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs".RNA.3 (12):1374–87.PMC 1369579.PMID 9404889.
^^a ^b"Entrez Gene: PRPF4 PRP4 pre-mRNA processing factor 4 homolog (yeast)".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".Gene.138 (1–2):171–4.doi:10.1016/0378-1119(94)90802-8.PMID 8125298.
Horowitz DS, Krainer AR (1997)."A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor".Genes Dev.11 (1):139–51.doi:10.1101/gad.11.1.139.PMID 9000057.
Wang A, Forman-Kay J, Luo Y, et al. (1997)."Identification and characterization of human genes encoding Hprp3p and Hprp4p, interacting components of the spliceosome".Hum. Mol. Genet.6 (12):2117–26.doi:10.1093/hmg/6.12.2117.PMID 9328476.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene.200 (1–2):149–56.doi:10.1016/S0378-1119(97)00411-3.PMID 9373149.
Heng HH, Wang A, Hu J (1998). "Mapping of the human HPRP3 and HPRP4 genes encoding U4/U6-associated splicing factors to chromosomes 1q21.1 and 9q31-q33".Genomics.48 (2):273–5.doi:10.1006/geno.1997.5181.PMID 9521884.
Kojima T, Zama T, Wada K, et al. (2001)."Cloning of human PRP4 reveals interaction with Clk1".J. Biol. Chem.276 (34):32247–56.doi:10.1074/jbc.M103790200.PMID 11418604.
Gonzalez-Santos JM, Wang A, Jones J, et al. (2002)."Central region of the human splicing factor Hprp3p interacts with Hprp4p".J. Biol. Chem.277 (26):23764–72.doi:10.1074/jbc.M111461200.PMID 11971898.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Reidt U, Wahl MC, Fasshauer D, et al. (2003)."Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide"(PDF).J. Mol. Biol.331 (1):45–56.doi:10.1016/S0022-2836(03)00684-3.hdl:11858/00-001M-0000-0012-F239-9.PMID 12875835.
Ingelfinger D, Göthel SF, Marahiel MA, et al. (2004)."Two protein-protein interaction sites on the spliceosome-associated human cyclophilin CypH".Nucleic Acids Res.31 (16):4791–6.doi:10.1093/nar/gkg660.PMC 169899.PMID 12907720.
Stanĕk D, Neugebauer KM (2004)."Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer".J. Cell Biol.166 (7):1015–25.doi:10.1083/jcb.200405160.PMC 2172029.PMID 15452143.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics".Nature.433 (7021):77–83.Bibcode:2005Natur.433...77A.doi:10.1038/nature03207.PMID 15635413.S2CID 4344740.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells".Science.307 (5715):1621–5.Bibcode:2005Sci...307.1621B.doi:10.1126/science.1105776.PMID 15761153.S2CID 39457788.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network".Nature.437 (7062):1173–8.Bibcode:2005Natur.437.1173R.doi:10.1038/nature04209.PMID 16189514.S2CID 4427026.
Liu S, Rauhut R, Vornlocher HP, Lührmann R (2006)."The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP".RNA.12 (7):1418–30.doi:10.1261/rna.55406.PMC 1484429.PMID 16723661.
Huang B, Ahn YT, McPherson L, et al. (2007)."Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription".J. Immunol.178 (11):7081–7.doi:10.4049/jimmunol.178.11.7081.PMC 2674583.PMID 17513757.

Post-transcriptional modification

Nuclear

RNA splicing

Intron / Exon snRNP Spliceosome minor U1 Alternative splicing
pre-mRNA factors	PLRG1 PRPF3 PRPF4 PRPF4B PRPF6 PRPF8 PRPF18 PRPF19 PRPF31 PRPF38A PRPF38B PRPF39 PRPF40A PRPF40B

Cytosolic

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