PRKD3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | PRKD3, EPK2, PKC-NU, PKD3, PRKCN, nPKC-NU, protein kinase D3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM:607077;MGI:1922542;HomoloGene:2055;GeneCards:PRKD3;OMA:PRKD3 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Serine/threonine-protein kinase D3 (PKD3) or PKC-nu is anenzyme that in humans is encoded by thePRKD3gene.[5][6]
Protein kinase C (PKC) is a family ofserine- and threonine-specific protein kinases that can be activated by calcium and the second messengerdiacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors forphorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. This kinase can be activated rapidly by the agonists ofG protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated afterB-cell antigen receptor (BCR) engagement, which requires intactphospholipase C gamma and the involvement of other PKC family members.[6]
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