Movatterモバイル変換


[0]ホーム

URL:


Jump to content
WikipediaThe Free Encyclopedia
Search

PRKD3

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
PRKD3
Available structures
PDBOrtholog search:PDBeRCSB
List of PDB id codes

2D9Z

Identifiers
AliasesPRKD3, EPK2, PKC-NU, PKD3, PRKCN, nPKC-NU, protein kinase D3
External IDsOMIM:607077;MGI:1922542;HomoloGene:2055;GeneCards:PRKD3;OMA:PRKD3 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for PRKD3
Genomic location for PRKD3
Band2p22.2Start37,250,502bp[1]
End37,324,833bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for PRKD3
Genomic location for PRKD3
Band17|17 E3Start79,256,834bp[2]
End79,328,245bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • buccal mucosa cell

  • sperm

  • corpus epididymis

  • tail of epididymis

  • skin of hip

  • parietal pleura

  • tibia

  • cartilage tissue

  • superficial temporal artery
Top expressed in
  • Rostral migratory stream

  • internal carotid artery

  • saccule

  • external carotid artery

  • vas deferens

  • condyle

  • efferent ductule

  • fossa

  • otic placode

  • renal corpuscle
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23683

75292

Ensembl

ENSG00000115825

ENSMUSG00000024070

UniProt

O94806

Q8K1Y2

RefSeq (mRNA)

NM_005813

NM_001171004
NM_001171005
NM_029239

RefSeq (protein)

NP_005804

NP_001164475
NP_001164476
NP_083515

Location (UCSC)Chr 2: 37.25 – 37.32 MbChr 17: 79.26 – 79.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase D3 (PKD3) or PKC-nu is anenzyme that in humans is encoded by thePRKD3gene.[5][6]

Protein kinase C (PKC) is a family ofserine- and threonine-specific protein kinases that can be activated by calcium and the second messengerdiacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors forphorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. This kinase can be activated rapidly by the agonists ofG protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated afterB-cell antigen receptor (BCR) engagement, which requires intactphospholipase C gamma and the involvement of other PKC family members.[6]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000115825Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000024070Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Hayashi A, Seki N, Hattori A, Kozuma S, Saito T (Jun 1999)."PKCnu, a new member of the protein kinase C family, composes a fourth subfamily with PKCmu".Biochim Biophys Acta.1450 (1):99–106.doi:10.1016/S0167-4889(99)00040-3.PMID 10231560.
  6. ^ab"Entrez Gene: PRKD3 protein kinase D3".

Further reading

[edit]
PDB gallery
  • 2d9z: Solution structure of the PH domain of Protein kinase C, nu type from human
    2d9z: Solution structure of the PH domain of Protein kinase C, nu type from human
Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
  • -
IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
  • -
Tropomyosin kinase (EC 2.7.11.28)
  • -
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
  • -
Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
Activity
Regulation
Classification
Kinetics
Types
Portal:


Stub icon

This article on agene on humanchromosome 2 is astub. You can help Wikipedia byexpanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=PRKD3&oldid=1215915109"
Categories:
Hidden categories:

[8]ページ先頭

©2009-2025 Movatter.jp