Protein-coding gene in the species Homo sapiens
Protein kinase C beta type is anenzyme that in humans is encoded by thePRKCB gene .[ 5]
Protein kinase C (PKC) is a family ofserine - andthreonine -specificprotein kinases that can be activated bycalcium andsecond messenger diacylglycerol . PKC family membersphosphorylate a wide variety of protein targets and are known to be involved in diversecellular signaling pathways. PKC family members also serve as major receptors forphorbol esters , a class oftumor promoters . Each member of the PKC family has a specificexpression profile and is believed to play a distinct role incells . The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such asB cell activation,apoptosis induction,endothelial cell proliferation , andintestinal sugar absorption. Studies inmice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress.Alternatively spliced transcript variants encoding distinctisoforms have been reported.[ 6] autism .[ 7] [ 8]
PRKCB1 has been shown tointeract withRIPK4 ,[ 9] beta adrenergic receptor kinase ,[ 10] PDLIM5 [ 11] GNB2L1 .[ 12]
^a b c GRCh38: Ensembl release 89: ENSG00000166501 –Ensembl , May 2017^a b c GRCm38: Ensembl release 89: ENSMUSG00000052889 –Ensembl , May 2017^ "Human PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ Kubo K, Ohno S, Suzuki K (September 1987)."Nucleotide sequence of the 3' portion of a human gene for protein kinase C beta I/beta II" .Nucleic Acids Research .15 (17):7179– 80.doi :10.1093/nar/15.17.7179 .PMC 306204 PMID 3658678 . ^ "Entrez Gene: PRKCB1 protein kinase C, beta 1" .^ Philippi A, Roschmann E, Tores F, Lindenbaum P, Benajou A, Germain-Leclerc L, et al. (October 2005)."Haplotypes in the gene encoding protein kinase c-beta (PRKCB1) on chromosome 16 are associated with autism" .Molecular Psychiatry .10 (10):950– 60.doi :10.1038/sj.mp.4001704 PMID 16027742 . ^ Lintas C, Sacco R, Garbett K, Mirnics K, Militerni R, Bravaccio C, et al. (July 2009)."Involvement of the PRKCB1 gene in autistic disorder: significant genetic association and reduced neocortical gene expression" .Molecular Psychiatry .14 (7):705– 18.doi :10.1038/mp.2008.21 hdl :11380/1250965 PMID 18317465 . ^ Chen L, Haider K, Ponda M, Cariappa A, Rowitch D, Pillai S (June 2001)."Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase" .The Journal of Biological Chemistry .276 (24):21737– 44.doi :10.1074/jbc.M008069200 PMID 11278382 . ^ Yang XL, Zhang YL, Lai ZS, Xing FY, Liu YH (April 2003)."Pleckstrin homology domain of G protein-coupled receptor kinase-2 binds to PKC and affects the activity of PKC kinase" .World Journal of Gastroenterology .9 (4):800– 3.doi :10.3748/wjg.v9.i4.800 PMC 4611453 PMID 12679936 . ^ Kuroda S, Tokunaga C, Kiyohara Y, Higuchi O, Konishi H, Mizuno K, et al. (December 1996)."Protein-protein interaction of zinc finger LIM domains with protein kinase C" .The Journal of Biological Chemistry .271 (49):31029– 32.doi :10.1074/jbc.271.49.31029 PMID 8940095 . ^ Ron D, Jiang Z, Yao L, Vagts A, Diamond I, Gordon A (September 1999)."Coordinated movement of RACK1 with activated betaIIPKC" .The Journal of Biological Chemistry .274 (38):27039– 46.doi :10.1074/jbc.274.38.27039 PMID 10480917 .
Activity Regulation Classification Kinetics Types
