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PRE-084

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
PRE-084
Clinical data
ATC code
  • none
Identifiers
  • 2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate
CAS Number
PubChemCID
IUPHAR/BPS
ChemSpider
UNII
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC19H27NO3
Molar mass317.429 g·mol−1
3D model (JSmol)
  • c1ccccc1C2(CCCCC2)C(=O)OCCN3CCOCC3
  • InChI=1S/C19H27NO3/c21-18(23-16-13-20-11-14-22-15-12-20)19(9-5-2-6-10-19)17-7-3-1-4-8-17/h1,3-4,7-8H,2,5-6,9-16H2 ☒N
  • Key:RQHKZUBCUZVZEF-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

PRE-084 is asigma receptoragonist, selective for theσ1 subtype. It hasnootropic andantidepressant actions in animal studies, as well asantitussive and reinforcing effects.[1][2][3][4][5] PRE-084 increases the expression ofGDNF.[6]

References

[edit]
  1. ^Maurice T, Su TP, Parish DW, Nabeshima T, Privat A (December 1994)."PRE-084, a sigma selective PCP derivative, attenuates MK-801-induced impairment of learning in mice".Pharmacology Biochemistry and Behavior.49 (4):859–69.doi:10.1016/0091-3057(94)90235-6.PMID 7886099.S2CID 54306053.
  2. ^Maurice T (November 2001). "Beneficial effect of the sigma(1) receptor agonist PRE-084 against the spatial learning deficits in aged rats".European Journal of Pharmacology.431 (2):223–7.doi:10.1016/S0014-2999(01)01436-4.PMID 11728429.
  3. ^Brown C, Fezoui M, Selig WM, Schwartz CE, Ellis JL (January 2004)."Antitussive activity of sigma-1 receptor agonists in the guinea-pig".British Journal of Pharmacology.141 (2):233–40.doi:10.1038/sj.bjp.0705605.PMC 1574192.PMID 14691051.
  4. ^Skuza G, Rogóz Z (2009). "Antidepressant-like effect of PRE-084, a selective sigma1 receptor agonist, in Albino Swiss and C57BL/6J mice".Pharmacological Reports.61 (6):1179–83.doi:10.1016/S1734-1140(09)70181-1.PMID 20081254.S2CID 96025873.
  5. ^Hiranita T, Soto PL, Tanda G, Katz JL (February 2010)."Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine".The Journal of Pharmacology and Experimental Therapeutics.332 (2):515–24.doi:10.1124/jpet.109.159236.PMC 2812106.PMID 19892920.
  6. ^Penas C, Pascual-Font A, Mancuso R, Forés J, Casas C, Navarro X (May 2011). "Sigma receptor agonist 2-(4-morpholinethyl)1 phenylcyclohexanecarboxylate (Pre084) increases GDNF and BiP expression and promotes neuroprotection after root avulsion injury".J. Neurotrauma.28 (5):831–40.doi:10.1089/neu.2010.1674.PMID 21332255.
σ1
σ2
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