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PPP1R2

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

PPP1R2

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
2O8A,2O8G

Identifiers

Aliases

PPP1R2, IPP-2, IPP2, protein phosphatase 1 regulatory inhibitor subunit 2, PPP1R2A

External IDs

OMIM:601792;MGI:1914099;HomoloGene:4546;GeneCards:PPP1R2;OMA:PPP1R2 - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3q29	Start	195,514,428bp^[1]
Band	3q29	End	195,543,386bp^[1]

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)^[2]

Band	16 B2\|16 21.41 cM	Start	31,070,355bp^[2]
Band	16 B2\|16 21.41 cM	End	31,094,095bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

biceps brachii

Skeletal muscle tissue of biceps brachii

Skeletal muscle tissue of rectus abdominis

muscle of thigh

sperm

jejunal mucosa

gastrocnemius muscle

bone marrow

vastus lateralis muscle

bone marrow cells

Top expressed in

granulocyte

superior frontal gyrus

tail of embryo

muscle of thigh

spermatocyte

lumbar spinal ganglion

genital tubercle

ventricular zone

aortic valve

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein serine/threonine phosphatase inhibitor activity protein phosphatase inhibitor activity protein binding
Cellular component	protein phosphatase type 1 complex
Biological process	glycogen metabolic process regulation of phosphoprotein phosphatase activity regulation of signal transduction generation of precursor metabolites and energy carbohydrate metabolic process negative regulation of phosphoprotein phosphatase activity
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


5504


66849

Ensembl


ENSG00000184203


ENSMUSG00000047714

UniProt


P41236


Q9DCL8

RefSeq (mRNA)


NM_001291504 NM_001291505 NM_006241 NM_001316325


NM_025800

RefSeq (protein)


NP_001278433 NP_001278434 NP_001303254 NP_006232


NP_080076

Location (UCSC)

Chr 3: 195.51 – 195.54 Mb

Chr 16: 31.07 – 31.09 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Protein phosphatase inhibitor 2 is anenzyme that in humans is encoded by thePPP1R2gene.^[5]^[6]^[7]

Interactions

[edit]

PPP1R2 has been shown tointeract withLMTK2^[8] andPPP1R9B.^[9]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000184203 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000047714 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Permana PA, Mott DM (April 1997)."Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians".Genomics.41 (1):110–4.doi:10.1006/geno.1997.4649.PMID 9126490.
^Helps NR, Street AJ, Elledge SJ, Cohen PT (February 1994)."Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli".FEBS Letters.340 (1–2):93–8.doi:10.1016/0014-5793(94)80179-7.PMID 8119416.S2CID 10674654.
^"Entrez Gene: PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2".
^Wang H, Brautigan DL (December 2002)."A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2".The Journal of Biological Chemistry.277 (51):49605–12.doi:10.1074/jbc.M209335200.PMID 12393858.
^Terry-Lorenzo RT, Elliot E, Weiser DC, Prickett TD, Brautigan DL, Shenolikar S (November 2002)."Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton".The Journal of Biological Chemistry.277 (48):46535–43.doi:10.1074/jbc.M206960200.PMID 12270929.

Sanséau P, Jackson A, Alderton RP, Beck S, Senger G, Sheer D, et al. (August 1994). "Cloning and characterization of human phosphatase inhibitor-2 (IPP-2) sequences".Mammalian Genome.5 (8):490–6.doi:10.1007/BF00369318.PMID 7949733.S2CID 11381670.
Park IK, Roach P, Bondor J, Fox SP, DePaoli-Roach AA (January 1994)."Molecular mechanism of the synergistic phosphorylation of phosphatase inhibitor-2. Cloning, expression, and site-directed mutagenesis of inhibitor-2".The Journal of Biological Chemistry.269 (2):944–54.doi:10.1016/S0021-9258(17)42203-4.PMID 8288648.
Kakinoki Y, Somers J, Brautigan DL (December 1997)."Multisite phosphorylation and the nuclear localization of phosphatase inhibitor 2-green fluorescent protein fusion protein during S phase of the cell growth cycle".The Journal of Biological Chemistry.272 (51):32308–14.doi:10.1074/jbc.272.51.32308.PMID 9405437.
Yang J, Hurley TD, DePaoli-Roach AA (July 2000)."Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif".The Journal of Biological Chemistry.275 (30):22635–44.doi:10.1074/jbc.M003082200.PMID 10807923.
Agarwal-Mawal A, Paudel HK (June 2001)."Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and phosphorylates inhibitor-2".The Journal of Biological Chemistry.276 (26):23712–8.doi:10.1074/jbc.M010002200.PMID 11320080.
Eto M, Elliott E, Prickett TD, Brautigan DL (November 2002)."Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation".The Journal of Biological Chemistry.277 (46):44013–20.doi:10.1074/jbc.M208035200.PMID 12221103.
Terry-Lorenzo RT, Elliot E, Weiser DC, Prickett TD, Brautigan DL, Shenolikar S (November 2002)."Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton".The Journal of Biological Chemistry.277 (48):46535–43.doi:10.1074/jbc.M206960200.PMID 12270929.
Wang H, Brautigan DL (December 2002)."A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2".The Journal of Biological Chemistry.277 (51):49605–12.doi:10.1074/jbc.M209335200.PMID 12393858.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides".Nature Biotechnology.21 (5):566–9.doi:10.1038/nbt810.PMID 12665801.S2CID 23783563.
Leach C, Shenolikar S, Brautigan DL (July 2003)."Phosphorylation of phosphatase inhibitor-2 at centrosomes during mitosis".The Journal of Biological Chemistry.278 (28):26015–20.doi:10.1074/jbc.M300782200.PMID 12697755.
Sakashita G, Shima H, Komatsu M, Urano T, Kikuchi A, Kikuchi K (February 2003). "Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells".Journal of Biochemistry.133 (2):165–71.doi:10.1093/jb/mvg020.PMID 12761178.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004)."Large-scale characterization of HeLa cell nuclear phosphoproteins".Proceedings of the National Academy of Sciences of the United States of America.101 (33):12130–5.Bibcode:2004PNAS..10112130B.doi:10.1073/pnas.0404720101.PMC 514446.PMID 15302935.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network".Nature.437 (7062):1173–8.Bibcode:2005Natur.437.1173R.doi:10.1038/nature04209.PMID 16189514.S2CID 4427026.
Yamada M, Ikeda Y, Yano M, Yoshimura K, Nishino S, Aoyama H, et al. (June 2006)."Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy".FASEB Journal.20 (8):1197–9.doi:10.1096/fj.05-5299fje.PMID 16627625.S2CID 911020.
King TD, Gandy JC, Bijur GN (November 2006)."The protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation and increases sarcoplasmic/endoplasmic reticulum calcium ATPase 2 levels".Experimental Cell Research.312 (18):3693–700.doi:10.1016/j.yexcr.2006.08.010.PMC 1885546.PMID 16987514.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006)."Global, in vivo, and site-specific phosphorylation dynamics in signaling networks".Cell.127 (3):635–48.doi:10.1016/j.cell.2006.09.026.PMID 17081983.S2CID 7827573.

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