Lipid phosphate phosphohydrolase 1 is a member of thephosphatidic acid phosphatase (PAP) family. PAPs convertphosphatidic acid todiacylglycerol, and function in de novo synthesis ofglycerolipids as well as in receptor-activated signal transduction mediated byphospholipase D. This protein is an integral membrane glycoprotein, and has been shown to be a surface enzyme that plays an active role in the hydrolysis and uptake of lipids from extracellular space. The expression of this gene is found to be regulated by androgen in a prostatic adenocarcinoma cell line. At least two alternatively spliced transcript variants encoding distinct isoforms have been described.[6]
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