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DNA polymerase kappa

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(Redirected fromPOLK)

Protein-coding gene in the species Homo sapiens

POLK

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
1T94,2LSI,2OH2,2W7O,2W7P,3IN5,3PZP,4BA9,4GK5,4U6P,4U7C

Identifiers

Aliases

POLK, DINB1, DINP, POLQ, polymerase (DNA) kappa, DNA polymerase kappa

External IDs

OMIM:605650;MGI:1349767;HomoloGene:32140;GeneCards:POLK;OMA:POLK - orthologs

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5q13.3	Start	75,511,756bp^[1]
Band	5q13.3	End	75,601,144bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Achilles tendon

corpus callosum

superficial temporal artery

epithelium of colon

mucosa of paranasal sinus

skin of hip

trabecular bone

monocyte

islet of Langerhans

synovial membrane

n/a

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	transferase activity damaged DNA binding DNA-directed DNA polymerase activity DNA binding nucleotidyltransferase activity metal ion binding protein binding
Cellular component	nucleoplasm nucleus nuclear body site of DNA damage
Biological process	nucleotide-excision repair, DNA gap filling DNA replication translesion synthesis transcription-coupled nucleotide-excision repair nucleotide-excision repair, DNA incision DNA biosynthetic process nucleotide-excision repair, DNA incision, 5'-to lesion DNA repair cellular response to DNA damage stimulus cellular response to UV error-prone translesion synthesis error-free translesion synthesis
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


51426


27015

Ensembl


ENSG00000122008


ENSMUSG00000021668

UniProt


Q9UBT6


Q9QUG2

RefSeq (mRNA)


NM_016218 NM_001345921 NM_001345922


NM_012048

RefSeq (protein)


NP_001332850 NP_001332851 NP_057302 NP_057302.1


NP_001334531 NP_001334532 NP_001334533 NP_001334535 NP_036178

Location (UCSC)

Chr 5: 75.51 – 75.6 Mb

n/a

PubMed search

^[2]

^[3]

Wikidata

View/Edit Human

View/Edit Mouse

DNA polymerase kappa is aDNA polymerase that in humans is encoded by thePOLKgene. It is involved intranslesion synthesis.^[4]^[5]^[6]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000122008 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ohashi E, Ogi T, Kusumoto R, Iwai S, Masutani C, Hanaoka F, Ohmori H (Aug 2000)."Error-prone bypass of certain DNA lesions by the human DNA polymerase κ".Genes Dev.14 (13):1589–94.doi:10.1101/gad.14.13.1589.PMC 316741.PMID 10887153.
^Gerlach VL, Aravind L, Gotway G, Schultz RA, Koonin EV, Friedberg EC (Nov 1999)."Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily".Proc Natl Acad Sci U S A.96 (21):11922–7.Bibcode:1999PNAS...9611922G.doi:10.1073/pnas.96.21.11922.PMC 18388.PMID 10518552.
^"Entrez Gene: POLK Polymerase (DNA directed) kappa".

Bavoux C, Hoffmann JS, Cazaux C (2005). "Adaptation to DNA damage and stimulation of genetic instability: the double-edged sword mammalian DNA polymerase kappa".Biochimie.87 (7):637–46.doi:10.1016/j.biochi.2005.02.007.PMID 15989980.
Ogi T, Kato T, Kato T, Ohmori H (2000)."Mutation enhancement by DINB1, a mammalian homologue of the Escherichia coli mutagenesis protein dinB".Genes Cells.4 (11):607–18.doi:10.1046/j.1365-2443.1999.00289.x.PMID 10620008.S2CID 6554870.
Johnson RE, Prakash S, Prakash L (2000)."The human DINB1 gene encodes the DNA polymerase Polθ".Proc. Natl. Acad. Sci. U.S.A.97 (8):3838–43.Bibcode:2000PNAS...97.3838J.doi:10.1073/pnas.97.8.3838.PMC 18103.PMID 10760255.
Gerlach VL, Feaver WJ, Fischhaber PL, Friedberg EC (2001)."Purification and characterization of pol kappa, a DNA polymerase encoded by the human DINB1 gene".J. Biol. Chem.276 (1):92–8.doi:10.1074/jbc.M004413200.PMID 11024016.
Haracska L, Unk I, Johnson RE, et al. (2002)."Stimulation of DNA Synthesis Activity of Human DNA Polymerase κ by PCNA".Mol. Cell. Biol.22 (3):784–91.doi:10.1128/MCB.22.3.784-791.2002.PMC 133560.PMID 11784855.
Washington MT, Johnson RE, Prakash L, Prakash S (2002)."Human DINB1-encoded DNA polymerase κ is a promiscuous extender of mispaired primer termini".Proc. Natl. Acad. Sci. U.S.A.99 (4):1910–4.Bibcode:2002PNAS...99.1910W.doi:10.1073/pnas.032594399.PMC 122293.PMID 11842189.
Suzuki N, Ohashi E, Kolbanovskiy A, et al. (2002). "Translesion synthesis by human DNA polymerase kappa on a DNA template containing a single stereoisomer of dG-(+)- or dG-(−)-anti-N(2)-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene)".Biochemistry.41 (19):6100–6.doi:10.1021/bi020049c.PMID 11994005.
Fischhaber PL, Gerlach VL, Feaver WJ, et al. (2002)."Human DNA polymerase kappa bypasses and extends beyond thymine glycols during translesion synthesis in vitro, preferentially incorporating correct nucleotides".J. Biol. Chem.277 (40):37604–11.doi:10.1074/jbc.M206027200.PMID 12145297.
Bergoglio V, Bavoux C, Verbiest V, et al. (2003). "Localisation of human DNA polymerase kappa to replication foci".J. Cell Sci.115 (Pt 23):4413–8.doi:10.1242/jcs.00162.PMID 12414988.S2CID 84437951.
Haracska L, Prakash L, Prakash S (2003)."Role of human DNA polymerase κ as an extender in translesion synthesis".Proc. Natl. Acad. Sci. U.S.A.99 (25):16000–5.doi:10.1073/pnas.252524999.PMC 138554.PMID 12444249.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Wolfle WT, Washington MT, Prakash L, Prakash S (2003)."Human DNA polymerase κ uses template–primer misalignment as a novel means for extending mispaired termini and for generating single-base deletions".Genes Dev.17 (17):2191–9.doi:10.1101/gad.1108603.PMC 196459.PMID 12952891.
Haracska L, Prakash L, Prakash S (2003)."A mechanism for the exclusion of low-fidelity human Y-family DNA polymerases from base excision repair".Genes Dev.17 (22):2777–85.doi:10.1101/gad.1146103.PMC 280626.PMID 14630940.
Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36 (1):40–5.doi:10.1038/ng1285.PMID 14702039.
Suzuki N, Itoh S, Poon K, et al. (2004). "Translesion synthesis past estrogen-derived DNA adducts by human DNA polymerases eta and kappa".Biochemistry.43 (20):6304–11.doi:10.1021/bi0360298.PMID 15147214.
Ohashi E, Murakumo Y, Kanjo N, et al. (2005). "Interaction of hREV1 with three human Y-family DNA polymerases".Genes Cells.9 (6):523–31.doi:10.1111/j.1356-9597.2004.00747.x.PMID 15189446.S2CID 24470762.
Washington MT, Minko IG, Johnson RE, et al. (2004)."Efficient and Error-Free Replication Past a Minor-Groove DNA Adduct by the Sequential Action of Human DNA Polymerases ι and κ".Mol. Cell. Biol.24 (13):5687–93.doi:10.1128/MCB.24.13.5687-5693.2004.PMC 480884.PMID 15199127.
Uljon SN, Johnson RE, Edwards TA, et al. (2005)."Crystal structure of the catalytic core of human DNA polymerase kappa".Structure.12 (8):1395–404.doi:10.1016/j.str.2004.05.011.PMID 15296733.

External links

[edit]

Overview of all the structural information available in thePDB forUniProt:Q9UBT6 (DNA polymerase kappa) at thePDBe-KB.

v t e PDB gallery
1t94: Crystal structure of the catalytic core of human DNA polymerase kappa 2oh2: Ternary Complex of Human DNA Polymerase

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