Protein-coding gene in the species Homo sapiens
Proline-rich nuclear receptor coactivator 1 is aprotein that, in humans, is encoded by thePNRC1 gene .[ 5] [ 6]
PNRC1 functions as acoactivator for severalnuclear receptors includingAR ,ERα ,ERRα ,ERRγ ,GR ,SF1 ,PR ,TR ,RAR andRXR .[ 7] [ 8] SH3 domain of PNRC1.[ 8]
^a b c GRCh38: Ensembl release 89: ENSG00000146278 –Ensembl , May 2017^a b c GRCm38: Ensembl release 89: ENSMUSG00000040128 –Ensembl , May 2017^ "Human PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ Chen J, Liu L, Pohajdak B (Dec 1995). "Cloning a cDNA from human NK/T cells which codes for a protein with high proline content".Biochim Biophys Acta .1264 (1):19– 22.doi :10.1016/0167-4781(95)00159-e .PMID 7578250 . ^ "Entrez Gene: PNRC1 proline-rich nuclear receptor coactivator 1" .^ Zhou D, Quach KM, Yang C, Lee SY, Pohajdak B, Chen S (July 2000)."PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1)" .Mol. Endocrinol .14 (7):986– 98.doi :10.1210/mend.14.7.0480 PMID 10894149 . ^a b Zhou D, Chen S (October 2001)."PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif" .Nucleic Acids Res .29 (19):3939– 48.doi :10.1093/nar/29.19.3939 .PMC 60244 PMID 11574675 . Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" .Genome Res .14 (10B):2121– 7.doi :10.1101/gr.2596504 .PMC 528928 PMID 15489334 . Zhou D, Chen B, Ye JJ, Chen S (2004)."A novel crosstalk mechanism between nuclear receptor-mediated and growth factor/Ras-mediated pathways through PNRC-Grb2 interaction" .Oncogene .23 (31):5394– 404.doi :10.1038/sj.onc.1207695 PMID 15122321 . Mungall AJ, Palmer SA, Sims SK, et al. (2003)."The DNA sequence and analysis of human chromosome 6" .Nature .425 (6960):805– 11.Bibcode :2003Natur.425..805M .doi :10.1038/nature02055 PMID 14574404 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" .Proc. Natl. Acad. Sci. U.S.A .99 (26):16899– 903.Bibcode :2002PNAS...9916899M .doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Hsiao PW, Chang C (1999)."Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells" .J. Biol. Chem .274 (32):22373– 9.CiteSeerX 10.1.1.621.2877 doi :10.1074/jbc.274.32.22373 PMID 10428808 .S2CID 15532327 .
