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PLK2

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

PLK2

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
4I5M,4I5P,4I6B,4I6F,4I6H,4RS6,4XB0

Identifiers

Aliases

PLK2, SNK, hPlk2, hSNK, polo like kinase 2

External IDs

OMIM:607023;MGI:1099790;HomoloGene:21317;GeneCards:PLK2;OMA:PLK2 - orthologs

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5q11.2	Start	58,453,982bp^[1]
Band	5q11.2	End	58,460,139bp^[1]

Gene location (Mouse)

Chr.	Chromosome 13 (mouse)^[2]

Band	13\|13 D2.1	Start	110,531,580bp^[2]
Band	13\|13 D2.1	End	110,537,378bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

spleen

apex of heart

canal of the cervix

ectocervix

islet of Langerhans

epithelium of colon

skin of abdomen

Achilles tendon

gallbladder

tibial nerve

Top expressed in

CA3 field

Region I of hippocampus proper

perirhinal cortex

entorhinal cortex

primary motor cortex

primary visual cortex

olfactory tubercle

choroid plexus of fourth ventricle

superior frontal gyrus

left lung lobe

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	transferase activity nucleotide binding protein kinase activity protein-containing complex binding signal transducer activity ATP-dependent protein binding kinase activity protein binding ATP binding protein serine/threonine kinase activity
Cellular component	cytoplasm centrosome cell projection intracellular anatomical structure dendrite centriole chromatin cytoskeleton cytosol
Biological process	positive regulation of protein catabolic process positive regulation of autophagy phosphorylation mitotic cell cycle checkpoint signaling G1 phase mitotic spindle organization Rap protein signal transduction regulation of centriole replication negative regulation of apoptotic process memory regulation of synaptic plasticity protein phosphorylation peptidyl-serine phosphorylation long-term depression mitotic cell cycle positive regulation of I-kappaB kinase/NF-kappaB signaling Ras protein signal transduction positive regulation of protein binding negative regulation of dendritic spine development positive regulation of proteasomal ubiquitin-dependent protein catabolic process long-term potentiation DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


10769


20620

Ensembl


ENSG00000145632


ENSMUSG00000021701

UniProt


Q9NYY3


P53351

RefSeq (mRNA)


NM_006622 NM_001252226


NM_152804

RefSeq (protein)


NP_001239155 NP_006613


NP_690017

Location (UCSC)

Chr 5: 58.45 – 58.46 Mb

Chr 13: 110.53 – 110.54 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Serine/threonine-protein kinase PLK2 is anenzyme that in humans is encoded by thePLK2gene.^[5]

Serum-induciblekinase is a member of the 'polo' family of serine/threonine protein kinases that have a role in normalcell division. [supplied by OMIM]^[5]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000145632 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000021701 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^^a ^b"Entrez Gene: PLK2 polo-like kinase 2 (Drosophila)".

Kauselmann G, Weiler M, Wulff P, et al. (1999)."The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity".EMBO J.18 (20):5528–39.doi:10.1093/emboj/18.20.5528.PMC 1171621.PMID 10523297.
Ouyang B, Li W, Pan H, et al. (1999)."The physical association and phosphorylation of Cdc25C protein phosphatase by Prk".Oncogene.18 (44):6029–36.doi:10.1038/sj.onc.1202983.PMID 10557092.
Holtrich U, Wolf G, Yuan J, et al. (2000)."Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages".Oncogene.19 (42):4832–9.doi:10.1038/sj.onc.1203845.PMID 11039900.
Liby K, Wu H, Ouyang B, et al. (2002). "Identification of the human homologue of the early-growth response gene Snk, encoding a serum-inducible kinase".DNA Seq.11 (6):527–33.doi:10.3109/10425170109041337.PMID 11696980.S2CID 46552280.
Shimizu-Yoshida Y, Sugiyama K, Rogounovitch T, et al. (2002). "Radiation-inducible hSNK gene is transcriptionally regulated by p53 binding homology element in human thyroid cells".Biochem. Biophys. Res. Commun.289 (2):491–8.doi:10.1006/bbrc.2001.5993.PMID 11716500.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99 (26):16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC 139241.PMID 12477932.
Ma S, Liu MA, Yuan YL, Erikson RL (2003). "The serum-inducible protein kinase Snk is a G1 phase polo-like kinase that is inhibited by the calcium- and integrin-binding protein CIB".Mol. Cancer Res.1 (5):376–84.PMID 12651910.
Matsuda A, Suzuki Y, Honda G, et al. (2003)."Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways".Oncogene.22 (21):3307–18.doi:10.1038/sj.onc.1206406.PMID 12761501.
Burns TF, Fei P, Scata KA, et al. (2003)."Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells".Mol. Cell. Biol.23 (16):5556–71.doi:10.1128/MCB.23.16.5556-5571.2003.PMC 166320.PMID 12897130.
Ma S, Charron J, Erikson RL (2003)."Role of Plk2 (Snk) in mouse development and cell proliferation".Mol. Cell. Biol.23 (19):6936–43.doi:10.1128/MCB.23.19.6936-6943.2003.PMC 193943.PMID 12972611.
Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36 (1):40–5.doi:10.1038/ng1285.PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14 (10B):2121–7.doi:10.1101/gr.2596504.PMC 528928.PMID 15489334.
Yogosawa S, Hatakeyama S, Nakayama KI, et al. (2006)."Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase".J. Biol. Chem.280 (50):41619–27.doi:10.1074/jbc.M508397200.PMID 16203730.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006)."Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes".Genome Res.16 (1):55–65.doi:10.1101/gr.4039406.PMC 1356129.PMID 16344560.
Park YY, Kim SH, Kim YJ, et al. (2007). "Polo-like kinase 2 gene expression is regulated by the orphan nuclear receptor estrogen receptor-related receptor gamma (ERRgamma)".Biochem. Biophys. Res. Commun.362 (1):107–13.Bibcode:2007BBRC..362..107P.doi:10.1016/j.bbrc.2007.07.170.PMID 17706602.
Matthew EM, Yen TJ, Dicker DT, et al. (2007)."Replication stress, defective S-phase checkpoint and increased death in Plk2-deficient human cancer cells".Cell Cycle.6 (20):2571–8.doi:10.4161/cc.6.20.5079.PMID 17912033.

Kinases:Serine/threonine-specific protein kinases (EC 2.7.11-12)

Serine/threonine-specific protein kinases (EC 2.7.11.1-EC 2.7.11.20)

Non-specific serine/threonine protein kinases (EC 2.7.11.1)	LATS1 LATS2 MAST1 MAST2 STK38 STK38L CIT ROCK1 SGK SGK2 SGK3 Protein kinase B AKT1 AKT2 AKT3 Ataxia telangiectasia mutated mTOR EIF-2 kinases PKR HRI EIF2AK3 EIF2AK4 Wee1 WEE1
Pyruvate dehydrogenase kinase (EC 2.7.11.2)	PDK1 PDK2 PDK3 PDK4
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)	AMP-activated protein kinase α PRKAA1 PRKAA2 β PRKAB1 PRKAB2 γ PRKAG1 PRKAG2 PRKAG3
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)	BCKDK BCKDHA BCKDHB
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)	IDH2 IDH3A IDH3B IDH3G
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)	STK4
Myosin-heavy-chain kinase (EC 2.7.11.7)	Aurora kinase Aurora A kinase Aurora B kinase Aurora C kinase
Fas-activated serine/threonine kinase (EC 2.7.11.8)	FASTK STK10
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)	-
IκB kinase (EC 2.7.11.10)	CHUK IKK2 TBK1 IKBKE IKBKG IKBKAP
cAMP-dependent protein kinase (EC 2.7.11.11)	Protein kinase A PRKACG PRKACB PRKACA PRKY
cGMP-dependent protein kinase (EC 2.7.11.12)	Protein kinase G PRKG1
Protein kinase C (EC 2.7.11.13)	Protein kinase C Protein kinase Cζ PKC alpha PRKCB1 PRKCD PRKCE PRKCH PRKCG PRKCI PRKCQ Protein kinase N1 PKN2 PKN3
Rhodopsin kinase (EC 2.7.11.14)	Rhodopsin kinase
Beta adrenergic receptor kinase (EC 2.7.11.15)	Beta adrenergic receptor kinase Beta adrenergic receptor kinase-2
G-protein coupled receptor kinases (EC 2.7.11.16)	GRK4 GRK5 GRK6
Ca2+/calmodulin-dependent (EC 2.7.11.17)	BRSK2 CAMK1 CAMK1A CAMK1B CAMK1D CAMK1G CAMK2 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 MLCK CASK CHEK1 CHEK2 DAPK1 DAPK2 DAPK3 STK11 MAPKAPK2 MAPKAPK3 MAPKAPK5 MARK1 MARK2 MARK3 MARK4 MELK MKNK1 MKNK2 NUAK1 NUAK2 OBSCN PASK PHKG1 PHKG2 PIM1 PIM2 PKD1 PRKD2 PRKD3 PSKH1 SNF1LK2 KIAA0999 STK40 SNF1LK SNRK SPEG TSSK2 Kalirin TRIB1 TRIB2 TRIB3 TRIO Titin DCLK1
Myosin light-chain kinase (EC 2.7.11.18)	MYLK MYLK2 MYLK3 MYLK4
Phosphorylase kinase (EC 2.7.11.19)	PHKA1 PHKA2 PHKB PHKG1 PHKG2
Elongation factor 2 kinase (EC 2.7.11.20)	EEF2K STK19
Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4

Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)

Polo kinase (EC 2.7.11.21)	PLK1 PLK2 PLK3 PLK4
Cyclin-dependent kinase (EC 2.7.11.22)	CDK1 CDK2 CDKL2 CDK3 CDK4 CDK5 CDKL5 CDK6 CDK7 CDK8 CDK9 CDK10 CDK12 CDC2L5 PCTK1 PCTK2 PCTK3 PFTK1 CDC2L1
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)	RPS6KA5 RPS6KA4 P70S6 kinase P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1
Mitogen-activated protein kinase (EC 2.7.11.24)	Extracellular signal-regulated MAPK1 MAPK3 MAPK4 MAPK6 MAPK7 MAPK12 MAPK15 C-Jun N-terminal MAPK8 MAPK9 MAPK10 P38 mitogen-activated protein MAPK11 MAPK13 MAPK14
MAP3K (EC 2.7.11.25)	MAP kinase kinase kinases MAP3K1 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAP3K8 RAFs ARAF BRAF KSR1 KSR2 MLKs MAP3K12 MAP3K13 MAP3K9 MAP3K10 MAP3K11 MAP3K7 ZAK CDC7 MAP3K14
Tau-protein kinase (EC 2.7.11.26)	TPK1 TTK GSK-3
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)	-
Tropomyosin kinase (EC 2.7.11.28)	-
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)	-
Receptor protein serine/threonine kinase (EC 2.7.11.30)	Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor

Dual-specificity kinases (EC 2.7.12)

MAP2K	MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1Oxidoreductases (list) EC2Transferases (list) EC3Hydrolases (list) EC4Lyases (list) EC5Isomerases (list) EC6Ligases (list) EC7Translocases (list)

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