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Protein inhibitor of activated STAT2

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(Redirected fromPIAS2)

Protein-coding gene in the species Homo sapiens

PIAS2

Available structures

Ortholog search:PDBe RCSB

List of PDB id codes
2ASQ,4FO9

Identifiers

PIAS2, ARIP3, DIP, MIZ, MIZ1, PIASX, PIASX-ALPHA, PIASX-BETA, SIZ2, ZMIZ4, Protein inhibitor of activated STAT2, protein inhibitor of activated STAT 2

External IDs

OMIM:603567;MGI:1096566;HomoloGene:20979;GeneCards:PIAS2;OMA:PIAS2 - orthologs

Gene location (Human)

Chr.	Chromosome 18 (human)^[1]

Band	18q21.1	Start	46,803,218bp^[1]
Band	18q21.1	End	46,920,160bp^[1]

Gene location (Mouse)

Chr.	Chromosome 18 (mouse)^[2]

Band	18\|18 E3	Start	77,152,904bp^[2]
Band	18\|18 E3	End	77,241,496bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

sperm

left testis

right testis

epithelium of colon

secondary oocyte

testicle

gastrocnemius muscle

buccal mucosa cell

cerebellar vermis

internal globus pallidus

Top expressed in

seminiferous tubule

spermatid

spermatocyte

ventricular zone

Gonadal ridge

ganglionic eminence

lens

tail of embryo

neural layer of retina

medial ganglionic eminence

More reference expression data


More reference expression data

Gene ontology
Molecular function	DNA binding transcription coactivator activity zinc ion binding transcription factor binding metal ion binding SUMO ligase activity ligase activity protein binding androgen receptor binding ubiquitin protein ligase binding SUMO transferase activity transferase activity
Cellular component	PML body nuclear speck nuclear body nucleoplasm nucleus
Biological process	androgen receptor signaling pathway regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II negative regulation of androgen receptor signaling pathway negative regulation of DNA-binding transcription factor activity transcription, DNA-templated positive regulation of transcription, DNA-templated regulation of osteoblast differentiation positive regulation of transcription by RNA polymerase II protein sumoylation
Sources:Amigo /QuickGO

Species

Human

Mouse


9063


17344


ENSG00000078043


ENSMUSG00000025423


O75928


Q8C5D8

RefSeq (mRNA)

NM_004671 NM_173206 NM_001324046 NM_001324047 NM_001324048
NM_001324049 NM_001324051 NM_001324052 NM_001324053 NM_001324054 NM_001324055 NM_001324057 NM_001324058 NM_001324059 NM_001324060 NM_001354033 NM_001354034 NM_001354035 NM_001354036 NM_001354037 NM_001354038 NM_001354039


NM_001164167 NM_001164168 NM_001164169 NM_001164170 NM_008602

RefSeq (protein)

NP_001310975 NP_001310976 NP_001310977 NP_001310978 NP_001310980
NP_001310981 NP_001310982 NP_001310983 NP_001310984 NP_001310986 NP_001310987 NP_001310988 NP_001310989 NP_004662 NP_775298 NP_001340962 NP_001340963 NP_001340964 NP_001340965 NP_001340966 NP_001340967 NP_001340968


NP_001157639 NP_001157640 NP_001157641 NP_001157642 NP_032628

Location (UCSC)

Chr 18: 46.8 – 46.92 Mb

Chr 18: 77.15 – 77.24 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

E3 SUMO-protein ligase PIAS2 is anenzyme that in humans is encoded by thePIAS2gene.^[5]^[6]^[7]

Interactions

Protein inhibitor of activated STAT2 has been shown tointeract with:

References

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000078043 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000025423 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Liu B, Liao J, Rao X, Kushner SA, Chung CD, Chang DD, Shuai K (September 1998)."Inhibition of Stat1-mediated gene activation by PIAS1".Proc Natl Acad Sci U S A.95 (18):10626–31.Bibcode:1998PNAS...9510626L.doi:10.1073/pnas.95.18.10626.PMC 27945.PMID 9724754.
^Wu L, Wu H, Ma L, Sangiorgi F, Wu N, Bell JR, Lyons GE, Maxson R (September 1997). "Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA".Mech Dev.65 (1–2):3–17.doi:10.1016/S0925-4773(97)00032-4.PMID 9256341.S2CID 11835268.
^"Entrez Gene: PIAS2 protein inhibitor of activated STAT, 2".
^Kotaja N, Aittomäki S, Silvennoinen O, Palvimo JJ, Jänne OA (December 2000)."ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation".Mol. Endocrinol.14 (12):1986–2000.doi:10.1210/mend.14.12.0569.PMID 11117529.
^Moilanen AM, Karvonen U, Poukka H, Yan W, Toppari J, Jänne OA, Palvimo JJ (February 1999)."A testis-specific androgen receptor coregulator that belongs to a novel family of nuclear proteins".J. Biol. Chem.274 (6):3700–4.doi:10.1074/jbc.274.6.3700.PMID 9920921.
^Ling Y, Sankpal UT, Robertson AK, McNally JG, Karpova T, Robertson KD (2004)."Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription".Nucleic Acids Res.32 (2):598–610.doi:10.1093/nar/gkh195.PMC 373322.PMID 14752048.
^Takahashi K, Taira T, Niki T, Seino C, Iguchi-Ariga SM, Ariga H (October 2001)."DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor".J. Biol. Chem.276 (40):37556–63.doi:10.1074/jbc.M101730200.PMID 11477070.
^Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J,Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network".Nature.437 (7062):1173–8.Bibcode:2005Natur.437.1173R.doi:10.1038/nature04209.PMID 16189514.S2CID 4427026.
^Lee BH, Yoshimatsu K, Maeda A, Ochiai K, Morimatsu M, Araki K, Ogino M, Morikawa S, Arikawa J (December 2003). "Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules".Virus Res.98 (1):83–91.doi:10.1016/j.virusres.2003.09.001.PMID 14609633.

Further reading

Cookson MR (2003)."Pathways to Parkinsonism".Neuron.37 (1):7–10.doi:10.1016/S0896-6273(02)01166-2.PMID 12526767.S2CID 14513509.
Moilanen AM, Karvonen U, Poukka H, Yan W, Toppari J, Jänne OA, Palvimo JJ (1999)."A testis-specific androgen receptor coregulator that belongs to a novel family of nuclear proteins".J. Biol. Chem.274 (6):3700–4.doi:10.1074/jbc.274.6.3700.PMID 9920921.
Minty A, Dumont X, Kaghad M, Caput D (2000)."Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif".J. Biol. Chem.275 (46):36316–23.doi:10.1074/jbc.M004293200.PMID 10961991.
Kotaja N, Aittomäki S, Silvennoinen O, Palvimo JJ, Jänne OA (2001)."ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation".Mol. Endocrinol.14 (12):1986–2000.doi:10.1210/mend.14.12.0569.PMID 11117529.
Gross M, Liu B, Tan J, French FS, Carey M, Shuai K (2001). "Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells".Oncogene.20 (29):3880–7.doi:10.1038/sj.onc.1204489.PMID 11439351.S2CID 12895068.
Takahashi K, Taira T, Niki T, Seino C, Iguchi-Ariga SM, Ariga H (2001)."DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor".J. Biol. Chem.276 (40):37556–63.doi:10.1074/jbc.M101730200.PMID 11477070.
Schmidt D, Müller S (2002)."Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity".Proc. Natl. Acad. Sci. U.S.A.99 (5):2872–7.Bibcode:2002PNAS...99.2872S.doi:10.1073/pnas.052559499.PMC 122440.PMID 11867732.
Tan JA, Hall SH, Hamil KG, Grossman G, Petrusz P, French FS (2002)."Protein inhibitors of activated STAT resemble scaffold attachment factors and function as interacting nuclear receptor coregulators".J. Biol. Chem.277 (19):16993–7001.doi:10.1074/jbc.M109217200.PMID 11877418.
Nishida T, Yasuda H (2003)."PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription".J. Biol. Chem.277 (44):41311–7.doi:10.1074/jbc.M206741200.PMID 12177000.
Tussie-Luna MI, Michel B, Hakre S, Roy AL (2003)."The SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2 is a transcriptional cofactor for TFII-I".J. Biol. Chem.277 (45):43185–93.doi:10.1074/jbc.M207635200.PMID 12193603.
Tussié-Luna MI, Bayarsaihan D, Seto E, Ruddle FH, Roy AL (2002)."Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxbeta".Proc. Natl. Acad. Sci. U.S.A.99 (20):12807–12.Bibcode:2002PNAS...9912807T.doi:10.1073/pnas.192464499.PMC 130541.PMID 12239342.
Miyauchi Y, Yogosawa S, Honda R, Nishida T, Yasuda H (2003)."Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes".J. Biol. Chem.277 (51):50131–6.doi:10.1074/jbc.M208319200.PMID 12393906.
Arora T, Liu B, He H, Kim J, Murphy TL, Murphy KM, Modlin RL, Shuai K (2003)."PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4".J. Biol. Chem.278 (24):21327–30.doi:10.1074/jbc.C300119200.PMID 12716907.
Ohshima T, Shimotohno K (2004)."Transforming growth factor-beta-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4".J. Biol. Chem.278 (51):50833–42.doi:10.1074/jbc.M307533200.PMID 14514699.
Lee BH, Yoshimatsu K, Maeda A, Ochiai K, Morimatsu M, Araki K, Ogino M, Morikawa S, Arikawa J (2004). "Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules".Virus Res.98 (1):83–91.doi:10.1016/j.virusres.2003.09.001.PMID 14609633.
Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region".Genomics.83 (1):153–67.doi:10.1016/S0888-7543(03)00235-0.PMID 14667819.

v
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JAK-STAT signaling pathway

Cytokine

Cytokine receptor

Adaptor proteins

STAT	STAT1 STAT2 STAT3 STAT4 STAT5 STAT6
PIAS	PIAS1 PIAS2 PIAS3 PIAS4
SOCS	1 2 3 4 5 6 7 CISH
IRF	IRF1 IRF2 IRF3 IRF4 IRF5 IRF6 IRF7 IRF8

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