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PFTK1

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
CDK14
Identifiers
AliasesCDK14, PFTAIRE1, PFTK1, cyclin-dependent kinase 14, cyclin dependent kinase 14
External IDsOMIM:610679;MGI:894318;HomoloGene:7888;GeneCards:CDK14;OMA:CDK14 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for CDK14
Genomic location for CDK14
Band7q21.13Start90,466,424bp[1]
End91,210,590bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for CDK14
Genomic location for CDK14
Band5 A1|5 2.61 cMStart4,853,391bp[2]
End5,470,312bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • postcentral gyrus

  • Region I of hippocampus proper

  • pars compacta

  • pars reticulata

  • lateral nuclear group of thalamus

  • entorhinal cortex

  • Brodmann area 10

  • superior frontal gyrus

  • Brodmann area 46

  • tendon of biceps brachii
Top expressed in
  • cingulate gyrus

  • habenula

  • medial dorsal nucleus

  • Amygdala

  • mammillary body

  • dentate gyrus

  • lateral geniculate nucleus

  • anterior amygdaloid area

  • pontine nuclei

  • medial geniculate nucleus
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

5218

18647

Ensembl

ENSG00000058091

ENSMUSG00000028926

UniProt

O94921

O35495

RefSeq (mRNA)

NM_001287135
NM_001287136
NM_001287137
NM_012395

NM_011074
NM_001310448

RefSeq (protein)

NP_001274064
NP_001274065
NP_001274066
NP_036527

NP_001297377
NP_035204

Location (UCSC)Chr 7: 90.47 – 91.21 MbChr 5: 4.85 – 5.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase PFTAIRE-1 is anenzyme that in humans is encoded by theCDK14gene.[5][6][7]

Interactions

[edit]

PFTK1 has been shown tointeract withSEPT8.[8]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000058091Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000028926Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Lazzaro MA, Albert PR, Julien JP (Jul 1997)."A novel cdc2-related protein kinase expressed in the nervous system".J Neurochem.69 (1):348–64.doi:10.1046/j.1471-4159.1997.69010348.x.PMID 9202329.S2CID 41686721.
  6. ^Yang T, Chen JY (Apr 2001). "Identification and cellular localization of human PFTAIRE1".Gene.267 (2):165–72.doi:10.1016/S0378-1119(01)00391-2.PMID 11313143.
  7. ^"Entrez Gene: PFTK1 PFTAIRE protein kinase 1".
  8. ^Yang, Tao; Gao Yan-Kun; Chen Jiang-Ye (Jul 2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1".Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao.34 (4). China:520–5.ISSN 0582-9879.PMID 12098780.

Further reading

[edit]
Non-specific serine/threonine protein kinases (EC 2.7.11.1)
Pyruvate dehydrogenase kinase (EC 2.7.11.2)
Dephospho-(reductase kinase) kinase (EC 2.7.11.3)
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.4)
(isocitrate dehydrogenase (NADP+)) kinase (EC 2.7.11.5)
(tyrosine 3-monooxygenase) kinase (EC 2.7.11.6)
Myosin-heavy-chain kinase (EC 2.7.11.7)
Fas-activated serine/threonine kinase (EC 2.7.11.8)
Goodpasture-antigen-binding protein kinase (EC 2.7.11.9)
  • -
IκB kinase (EC 2.7.11.10)
cAMP-dependent protein kinase (EC 2.7.11.11)
cGMP-dependent protein kinase (EC 2.7.11.12)
Protein kinase C (EC 2.7.11.13)
Rhodopsin kinase (EC 2.7.11.14)
Beta adrenergic receptor kinase (EC 2.7.11.15)
G-protein coupled receptor kinases (EC 2.7.11.16)
Ca2+/calmodulin-dependent (EC 2.7.11.17)
Myosin light-chain kinase (EC 2.7.11.18)
Phosphorylase kinase (EC 2.7.11.19)
Elongation factor 2 kinase (EC 2.7.11.20)
Polo kinase (EC 2.7.11.21)
Serine/threonine-specific protein kinases (EC 2.7.11.21-EC 2.7.11.30)
Polo kinase (EC 2.7.11.21)
Cyclin-dependent kinase (EC 2.7.11.22)
(RNA-polymerase)-subunit kinase (EC 2.7.11.23)
Mitogen-activated protein kinase (EC 2.7.11.24)
MAP3K (EC 2.7.11.25)
Tau-protein kinase (EC 2.7.11.26)
(acetyl-CoA carboxylase) kinase (EC 2.7.11.27)
  • -
Tropomyosin kinase (EC 2.7.11.28)
  • -
Low-density-lipoprotein receptor kinase (EC 2.7.11.29)
  • -
Receptor protein serine/threonine kinase (EC 2.7.11.30)
MAP2K
Activity
Regulation
Classification
Kinetics
Types
Portal:


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