The PFKP gene encodes the platelet isoform ofphosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion offructose 6-phosphate tofructose 1,6-bisphosphate and is a key regulatory enzyme inglycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM) and liver (PFKL) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Full tetrameric phosphofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2.[5][6]
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Hannemann A, Jandrig B, Gaunitz F, et al. (2005). "Characterization of the human P-type 6-phosphofructo-1-kinase gene promoter in neural cell lines".Gene.345 (2):237–47.doi:10.1016/j.gene.2004.11.018.PMID15716112.
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Overview of all the structural information available in thePDB forUniProt:Q01813 (Human ATP-dependent 6-phosphofructokinase, platelet type) at thePDBe-KB.
